Research published online in Nature on March 19, 2025, closely examines the changes occurring in the gastric epithelium during the progression toward cancer development. Certain mutations that occur in normal, nonreproductive cells over time can make these cells more prone to becoming cancerous later. The project began as a collaboration between the labs of Mike Stratton at the Sanger Institute and Suet Yi Leung from the University of Hong Kong, funded by the Wellcome Trust and the Kadoorie Charitable Foundation.