Treatment with injections of gonadotropin-releasing hormone, indicated to prevent sexual maturation deficits in Down syndrome, also reduced cognitive function impairment associated Down syndrome, also called trisomy 21.

Trisomy 21, the abnormal third copy of chromosome 21 causing developmental disorders in Down syndrome, has been shown to promote reorganization of the entire neural progenitor cell (NPC) genome, with the resulting gene transcription and cell function disruption being so similar to senescence that anti-senescence drugs could correct them in cell cultures.