As organisms adapt to their environment, adaptations that serve them in their current environment can become liabilities if that environment changes. The control of traits that are an asset in one situation and a liability by the same gene is called antagonistic pleiotropy. In the March 16, 2020, online issue of Nature Genetics, researchers reported a method to systematically identify mutations that conferred antagonistic pleiotropy – in the form of resistance to one drug, but heightened sensitivity to another – in acute myeloid leukemia (AML) cells.
Keeping you up to date on recent developments in neurology, including: Using AI for neonatal brain image segmentation; New imaging method sheds light on AD; Investigation of inherited mutations in ASD.
BioWorld looks at translational medicine, including: How the eye cleans itself up; In blood stem cells, selection drives driver mutations early on; Dead cells do tell tales; Selective TGF-beta inhibition helps checkpoint blockade; How lung tumors seed to brain; Butyrate affects regulatory B cells, rheumatoid arthritis; Lamin A/C’s presence in nucleus, absence from membrane both problematic in progeria; Females, males have different metabolic response to intermittent fasting; Ditching PAMs expands CRISPR.
Keeping you up to date on recent developments in diagnostics, including: Improving TBI prognosis; Speeding detection of antibiotic resistant infections; Multistep method wrests causality from GWAs; In blood stem cells, selection drives driver mutations early on.
Keeping you up to date on recent developments in orthopedics, including: First glimpse of body's 'steering wheel' joint sparks hope; Using CRISPR to find muscular dystrophy treatments; Fracture liaison service improves care for patients with fragility fractures.
Targeting glycosylated PD-1 immune checkpoint may be a promising new cancer immunotherapeutic strategy, according to a collaborative study led by Taiwanese researchers, which was reported online in Cancer Research.
Keeping you up to date on recent developments in oncology, including: New study hints that 3D chromatin architecture a key in childhood leukemia; Recruiting NK cells to the antitumor battle; 3D printing meets the medical isotope business.
Keeping you up to date on recent developments in cardiology, including: Hypertension-related deaths on the rise in the U.S.; Findings: Eating protein could ward off AF in women; Researchers: Assessing patients soon after stroke can help link brain regions, speech functions.
Keeping you up to date on recent developments in neurology, including: ‘Natural killer’ cells could halt PD progression; Neuroinflammation linked to several forms of dementia; GOF, LOF mutations take different paths to same result; Study links GABA, mitochondria, social defects.
LONDON – The extent to which existing DNA databases fail to reflect human genetic diversity is laid bare in the most geographically comprehensive sequencing initiative to date. The study applied the latest sequencing techniques to 929 genomes from 54 diverse populations around the world.