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BioWorld - Thursday, May 19, 2022
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Neurology illustration

Researchers discover HDAC1 as the cause of immune abnormalities in autistic mouse models

May 5, 2022
By Tamra Sami
No Comments
Researchers from the RIKEN Brain Science Institute in Japan have shown in mouse models that idiopathic autism could be caused by epigenetic abnormalities in hematopoietic cells during fetal development which resulted in immune dysregulation in the brain and gut.
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Lymph nodes

In times of need, fat cells take on immune functions

May 4, 2022
By Anette Breindl
No Comments
Fat cells surrounding the lymph nodes could switch jobs in response to a distant infection, taking on immune cell functions, researchers at Johns Hopkins University reported in the May 3, 2022, online issue of Cell Metabolism.
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3D illustration of heart cross section

Tripartite interactions between nervous system, immune cells and plaques drive atherosclerosis

May 3, 2022
By Subhasree Nag
No Comments
In a study reported in the April 27, 2022, online edition of Nature, an international team of researchers has for the first time demonstrated a three-way interaction between neurons, immune cells and plaques as a key component of atherosclerosis.
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Cancer cell and DNA

To escape radiation, tumor cells reversibly damage their DNA

May 2, 2022
By Nuala Moran
No Comments
Researchers have uncovered a new pathway via which cancer cells evade the effects of radiation by deploying self-inflicted – but reversible – DNA breaks to stop the cell cycle and ensure their survival. The lesions are caused by caspase-activated DNase (CAD), an enzyme involved in DNA fragmentation during cell death. In response to radiation, tumor cells activate CAD, causing genome-wide DNA breaks at sites involved in DNA repair.
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Inflammation illustration

Innate immune memory underlies inflammatory comorbidities: study

May 2, 2022
By Anette Breindl
No Comments
Researchers at the University of Pennsylvania have gained new insight into how different inflammatory conditions reinforce each other via trained innate immunity.
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Cancer cell and DNA

To escape radiation, tumor cells reversibly damage their DNA

April 29, 2022
By Nuala Moran
No Comments
Researchers have uncovered a new pathway via which cancer cells evade the effects of radiation by deploying self-inflicted – but reversible – DNA breaks to stop the cell cycle and ensure their survival.
Read More
Multiple sclerosis

Study finds targets of T-cell response in multiple sclerosis

April 28, 2022
By Anette Breindl
No Comments
Screening a panel of potential autoantigens, investigators at the Karolinska Institute have identified four autoantigens that are targeted by the T cells of multiple sclerosis patients.
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Antibiotic resistant bacteria inside a biofilm,

ECCMID 2022: In antibiotic development, scientific ingenuity meets a dysfunctional marketplace

April 26, 2022
By Anette Breindl
No Comments
Antibiotics drugs discovery, Ursula Theuretzbacher told the audience at the 2022 European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), has more than one challenge to overcome.
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Gene editing illustration

Researchers develop gene-editing platform to edit mitochondrial DNA

April 26, 2022
By Tamra Sami
No Comments
Researchers from the Center for Genome Engineering within South Korea's Institute for Basic Science have developed a new gene-editing platform that could be the final missing piece of the puzzle in gene-editing technology, by making editing of mitochondrial DNA possible.
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Human anatomy

Sex disparities of lupus recapitulated in mouse model

April 25, 2022
By Anette Breindl
No Comments
A new animal model of systemic lupus erythematosus (lupus) could be useful for understanding the disparity of the disorder, which is vastly more common in women than men.
Read More
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