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BioWorld - Wednesday, May 31, 2023
Home » Topics » Science

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The Combat of Rama and Ravana.
Cancer

ENA 2022: Mutant specific or target selective, that is the question for drug development

Oct. 27, 2022
By Mar de Miguel and Anette Breindl
No Comments
Diwali, the Festival of Light, marks different events depending on where it is celebrated. In some areas of India, it marks the return of Lord Rama to his birthplace of Ayodhya after defeating the demon Ravana. For Vivek Subbiah, associate professor at the Department of Investigational Cancer Therapeutics, Division of Cancer Medicine of the MD Anderson Cancer Center, the story of how Rama defeated Ravana has parallels in drug discovery. Ravana had 10 heads, and when one was cut off, it grew back. Rama defeated Ravana by means of a magic arrow that entered through the demon’s navel.
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Brain mapping illustration

Precision psychiatry, marching to the beat of its own drummer

Oct. 25, 2022
By Anette Breindl
No Comments
There is little doubt that progress in many brain diseases is being hampered because many, maybe most, diagnostic categories do not reflect underlying brain processes. In other disease areas, modern genetic and genomic methods have arrived in the form of approved drugs, from KRAS inhibitors in cancer to PCSK9 inhibitors to lower cholesterol. But brain diseases are different. Psychiatry is simultaneously the most personal area of medicine, and the least precise.
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Illustration of stomach, beneficial gut bacteria.

Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease

Oct. 25, 2022
By Mar de Miguel
No Comments
Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.
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Illustration of stomach, beneficial gut bacteria.

Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease

Oct. 21, 2022
By Mar de Miguel
No Comments
Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.
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Brain waves
ECNP 2022

ECNP 2022: Epilepsy is much more than seizures, studies suggest

Oct. 17, 2022
By Anette Breindl
No Comments
“Epilepsy is really a classical neurological disorder,” Lars Pinborg told the audience at the European College of Neuropsychopharmacology (ECNP) annual conference on Sunday. “Or is it?” Pinborg, of Rigshospitalet's The Neuroscience Center in Denmark, was chairing a session dedicated to an alternative hypothesis, summed up in the session title: “Is epilepsy a psychiatric disorder?”
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Genetic factors shown to influence COVID vaccine responses

Oct. 17, 2022
By Nuala Moran
No Comments
Differences in individual responses to COVID-19 vaccines have been linked directly to different human leukocyte antigen (HLA) alleles and it has been shown that people carrying one specific variant, HLA-DQB1*06, generate higher antibody responses and are better protected from SARS-CoV-2 infection.
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Healthy brain and brain with severe Alzheimer's disease

Soluble amyloid-β more important to cognition than plaques: study

Oct. 11, 2022
By Anette Breindl
No Comments
Researchers at the University of Cincinnati have published data showing that in patients with dominantly inherited Alzheimer’s disease-causing mutations, high levels of soluble amyloid-β42 (Aβ42) in the cerebrospinal fluid predicted a reduced risk of developing dementia over three years.
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Worms in a petri dish.
Biomarkers

Aging biomarkers may not generalize to lifespan

Oct. 7, 2022
By Anette Breindl
No Comments
By independently manipulating the lifespan of worms and one of its purported biomarkers, namely, the cessation of vigorous movement (CVM), investigators at the Center for Genomic Regulation (CRG) in Barcelona have demonstrated that the two are driven by partly independent processes.
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Concept illustration of click chemistry.
Drug Design, Drug Delivery & Technologies

Promoting attachments nets 2022’s Nobel Prize in Chemistry

Oct. 5, 2022
By Anette Breindl and Mar de Miguel
No Comments
The 2022 Nobel Prize in chemistry was awarded to Carolyn Bertozzi of Stanford University, to Morten Meldal of the University of Copenhagen, and – for the second time – to Barry Sharpless of The Scripps Research Institute “for the development of click chemistry and bioorthogonal chemistry.”

Click chemistry, the Nobel Committee’s Olof Ramström told reporters while announcing the prize, “is almost like it sounds – it’s all about linking different molecules.”

He likened click chemistry to a seatbelt buckle, whose interlocking parts can be attached to many different materials, linking them by snapping the two parts of the buckle together.

“The problem was to find good chemical buckles,” Ramström said – chemicals that “will easily snap together, and importantly, they won’t snap with anything else.”
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Illustration of scientist cutting DNA with scissors.
Drug Design, Drug Delivery & Technologies

CRISPR activation mouse model can turn on previously silenced genes

Oct. 4, 2022
By Tamra Sami
No Comments
Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia, have developed a new genome editing technique than can activate any gene, including those that have been silenced, allowing new drug targets and causes of drug resistance to be explored.
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