BioWorld looks at translational medicine, including: Healthspan, lifespan affected differently by caloric restriction; Stroke protection effects like night and day; Oncometabolites mask DNA repair signals; Antiviral vaccine protects against myocarditis, diabetes; C12orf49 is new lipid metabolism gene; Base editing gives temporary hearing fix; Simultaneous dual base editing; Nuclear quality control by chaperones; Stress-induced mutagenesis leads to cancer drug resistance.
Keeping you up to date on recent developments in diagnostics, including: Improving diagnosis of prostate cancer; Assay system identifies mitochondria-targeting drugs for PD; Ovarian organoids implicate oviducts.
Two major papers on repurposed drugs for COVID-19 by researchers from Brigham and Women’s Hospital face intense skepticism from the research community, prompting the editorial boards of TheNew England Journal of Medicine and The Lancet to publish Expressions of Concern on the validity of the underlying data. Such expressions are often the first step toward an outright retraction.
Keeping you up to date on recent developments in orthopedics, including: IMPACT study shows 25% reduction in health care costs associated with earlier prosthetic care; Human growth hormone treatment after ACL injury may prevent loss of muscle strength; Osteoporosis treatment may also protect against pneumonia.
Keeping you up to date on recent developments in oncology, including: Hydrogen plus gemcitabine may prove efficacious in treatment of bladder cancer; Tumor types have distinct microbiomes; Kinase helps prepare pre-metastatic niche; EZH2 has dual role; Sulfur-for-oxygen switch enables photosensitizers for cancer therapy.
In emergency situations, broad-spectrum antibiotics have their place. But their indiscriminate use has led to a resistance crisis that already kills tens of thousands of people annually in the U.S. alone.
Investigators are working to develop electrogenetic devices that use remote-controlled electrical stimulation to elicit specific behaviors in engineered cells. They are following in the footsteps of optogenetics, which use specific wavelengths of light to control cell function remotely. A new study published in Science used such a device paired with encapsulated, engineered human pancreatic beta cells to express enough insulin to restore normal glycemic levels in mice models of diabetes.