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BioWorld - Wednesday, May 31, 2023
Home » Topics » Science

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Lasker awards 2022

Laskers go for integrins, prenatal testing, COVID-19 dashboard

Oct. 4, 2022
By Anette Breindl
No Comments
The 2022 Albert Lasker Basic Medical Research Award has been awarded to Richard Hynes, of the Massachusetts Institute of Technology, Erkki Ruoslahti, of the Sanford Burnham Prebys Medical Discovery Institute, and Timothy Springer, of Harvard Medical School.
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Illustration of world map, DNA.
Biomarkers

Current TMB estimation methods fall short in minority populations

Oct. 4, 2022
By Mar de Miguel
No Comments
Tumor mutational burden (TMB), a biomarker used to assess whether a patient will respond to immunotherapy, needs to be recalculated in order to be useful for patients of Asian or African descent. Scientists at the Dana-Farber Cancer Institute found a significant bias in the estimated TMB values affecting these populations and adjusted them for those patients.
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Svante Pääbo with skull
Genetic/Congenital

From ancient DNA, a Nobel Prize, and perhaps modern drug targets

Oct. 3, 2022
By Mar de Miguel and Anette Breindl
No Comments
The Nobel Prize in Physiology or Medicine 2022 was awarded to Svante Pääbo today "for his discoveries concerning the genomes of extinct hominins and human evolution." Pääbo, who is currently the director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and his colleagues overcame extreme technical challenges to sequence the DNA of ancient hominids – because after tens of thousands of years, there is no such thing as aging well for DNA.
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Lasker awards 2022

Laskers go for integrins, prenatal testing, COVID-19 dashboard

Sep. 29, 2022
By Anette Breindl
No Comments
The 2022 Albert Lasker Basic Medical Research Award has been awarded to Richard Hynes, of the Massachusetts Institute of Technology, Erkki Ruoslahti, of the Sanford Burnham Prebys Medical Discovery Institute, and Timothy Springer, of Harvard Medical School “for discoveries concerning the integrins, key mediators of cell-matrix and cell-cell adhesion in physiology and disease.”
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Illustration of scientist cutting DNA with scissors.
Drug Design, Drug Delivery & Technologies

CRISPR activation mouse model can turn on previously silenced genes

Sep. 28, 2022
By Tamra Sami
No Comments
Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia, have developed a new genome editing technique than can activate any gene, including those that have been silenced, allowing new drug targets and causes of drug resistance to be explored.
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Bears at the WSU Bear Center.
Endocrine/Metabolic

Research identifies proteins that let sleeping bears lie

Sep. 22, 2022
By Anette Breindl
No Comments
Investigators at Washington State University (WSU) have identified a set of eight proteins that were expressed in the serum of Ursus arctos horribilis, better known as the grizzly bear, specifically during their hibernation period. In addition to reporting new basic insights into hibernation, the study, which was published in the Sept. 21, 2022, issue of iScience, could also give clues to insulin resistance and its relationship to body fat.
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Illustration of brain between man and woman
Cancer

Sex differences in brain tumor metabolism suggest the need to adapt treatments

Sep. 16, 2022
By Mar de Miguel
No Comments
Sex differences at the cellular level could explain why men respond less well to glioblastoma (GBM) treatments, according to a study led by the Washington University School of Medicine in St. Louis (WUSTL). The researchers found that male and female GBM tumor cells had different metabolic needs. GBM cells from male surgical samples absorbed more glutamine and had different nutritional preferences for amino acids.
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Drug Design, Drug Delivery & Technologies

Combination strategy enables brain-specific kinase inhibition

Sep. 15, 2022
By Anette Breindl
No Comments
Using a two-drug combination, researchers at the University of California at San Francisco (UCSF) have been able to achieve brain-specific inhibition of several kinases.
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Cerebral cortex map

‘Cognitive’ brain models sneak in sociodemographics, researchers find

Sep. 7, 2022
By Anette Breindl
No Comments
How well connectomic models of the brain could be used to the predict performance of a specific person on cognitive tests was influenced by sociodemographic characteristics of that person, such as age and education. The findings, which were published in the Aug. 25, 2022, issue of Nature, suggest that models of cognition “are not predicting unitary cognitive constructs, such as episodic memory. Rather, they are predicting composites: measures of these constructs intertwined with sociodemographic and clinical covariates,” first author Abigail Greene told BioWorld.
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Functional ULM

Functional ultrasound microscopy visualizes whole brain neuronal activity at the micro level

Sep. 6, 2022
By Bernard Banga
No Comments
Researchers from ESPCI Paris (Paris University for Industrial Physics and Chemistry), are working on a novel functional neuroimaging technique for measuring whole-brain activity dynamically at the microscopic level.
Read More
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