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BioWorld - Sunday, May 28, 2023
Home » Topics » Science

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Reindeer in field

Reindeer and horses and bears, oh my!

Jan. 3, 2023
By Anette Breindl
No Comments
One of the snarkier ways to describe psychology – and unfortunately, not a completely incorrect one – is as the study of behavior in white rats and college sophomores. For a long time, biomedical research suffered a parallel problem: of white mice and white men. Things are slowly improving as far as diversity in clinical research is concerned, and there are a number of species other than mice that are widely used because they are well-suited to study certain processes.
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Comparison of senescent cells in regenerating muscle.
Musculoskeletal

Senescent cells are toxic to their neighbors, prevent muscle regeneration

Dec. 22, 2022
By Mar de Miguel
No Comments
The first in vivo cell atlas of senescent tissue in skeletal muscle has identified the damaging properties of these cells and explained why they block muscle regeneration. According to a study at Pompeu Fabra University led by scientists from Altos Labs Inc., cell damage caused the senescence of the cells, which secreted toxic substances into the surrounding microenvironment, causing fibrosis and preventing tissue regeneration.
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Reindeer in snow
Dermatologic

Path to scarless healing could be among the gifts reindeer bring

Dec. 14, 2022
By Anette Breindl
No Comments
Unlike amphibians, mammals do not regenerate appendages. Except when they do. “If you amputate one of the branches off of the antler [of a reindeer], it will also regenerate,” Jeff Biernaskie told BioWorld. Even without amputation, the antlers of both male and female reindeer regenerate annually, including their skin. That regeneration is “the only large mammal model of true skin regeneration,” he said.
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Fat targeting illustration
Endocrine/Metabolic

Nanomaterial allows location-specific fat targeting

Dec. 13, 2022
By Anette Breindl
No Comments
The positively charged nanoparticle polyamidoamine generation 3 (P-G3) can be specifically targeted to either visceral or subcutaneous fat, and affects both types of fat in different ways, researchers from Columbia University reported in two papers recently published.
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Fat targeting illustration
Endocrine/Metabolic

Nanomaterial allows location-specific fat targeting

Dec. 7, 2022
By Anette Breindl
No Comments
The positively charged nanoparticle polyamidoamine generation 3 (P-G3) can be specifically targeted to either visceral or subcutaneous fat, and affects both types of fat in different ways, researchers from Columbia University reported in two papers recently published. The studies, published online in Nature Nanotechnology on Dec. 1, 2022, and in Biomaterials on Nov. 28, 2022, are both “a conceptual advance” and “quite amenable to translation,” co-corresponding author Kam Leong told BioWorld.
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Neurons and amyloid plaques

Amyloid plaques recast as cause of neural network dysfunction

Dec. 6, 2022
By Anette Breindl
No Comments
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
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Illustration of the spike glycoprotein structure of SARS-CoV and linoleic acid molecules.
Infection

Conserved binding pocket is net positive for deadly coronavirus strains

Dec. 5, 2022
By Anette Breindl
No Comments
Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The findings, which were published in the Nov. 23, 2022, issue of Science Advances, could form the basis of universal COVID antivirals, putting an end to the endless race to deal with new variants that has so far been a necessity.
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Neurons and amyloid plaques

Amyloid plaques recast as cause of neural network dysfunction

Nov. 30, 2022
By Anette Breindl
No Comments
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
Read More
Scanning electron micrograph of a macrophage.
Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 29, 2022
By Anette Breindl
No Comments
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer.
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Scanning electron micrograph of a macrophage.
Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 23, 2022
By Anette Breindl
No Comments
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer. The findings are “the first demonstration of T-cell-independent abscopal response,” co-corresponding author Edward Graves told BioWorld. “We’re not trying to say that all abscopal responses are macrophage-mediated. There are plenty that require T cells,” Graves clarified. But “there is another avenue of abscopal responses that has not been reported. ... All the abscopal literature is about stimulating an adaptive response.”
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