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BioWorld - Thursday, May 19, 2022
Home » Topics » Science

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Microscopic visualization of a cancerous cell

EBV antibodies put to good use through retargeting

Feb. 22, 2022
By Anette Breindl
No Comments
Researchers at Inserm have developed a method to direct pre-existing antibodies toward new targets. Their bimodular fusion proteins could be a broadly useful method for expanding access to antibody therapy. In a study that appeared in the Feb. 11, 2022, issue of Science Advances, the teams showed that antibodies to Epstein-Barr virus (EBV), which are present in 95% of the global population, could be redirected to a target cell of their choosing by fusing an EBV antigen to a cellular targeting ligand.
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Neurology illustration

Engineered Wnt ligands repair BBB in neuro disorders

Feb. 22, 2022
By John Fox
No Comments
An international study led by scientists at the Free University of Brussels in Belgium has shown that Wnt ligand signaling specificity is adjustable and may represent a means of treating CNS disorders by normalizing blood-brain barrier (BBB) function.
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Rendering of splint on trachea

Georgia Tech 3D-printed splint to sub for missing windpipe in newborns

Feb. 18, 2022
By David Godkin
No Comments
Engineers at Atlanta-based Georgia Tech’s Center for 3D Medical Fabrication have developed a 3D-printed tracheal splint as an airway for children born with a rare condition known as tracheal agenesis or the absence of a trachea or windpipe.
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Microscopic visualization of a cancerous cell

EBV antibodies put to good use through retargeting

Feb. 18, 2022
By Anette Breindl
No Comments
Researchers at Inserm have developed a method to direct pre-existing antibodies toward new targets. Their bimodular fusion proteins could be a broadly useful method for expanding access to antibody therapy. In a study that appeared in the Feb. 11, 2022, issue of Science Advances, the teams showed that antibodies to Epstein-Barr virus (EBV), which are present in 95% of the global population, could be redirected to a target cell of their choosing by fusing an EBV antigen to a cellular targeting ligand.
Read More
HIV-infected T cells

CROI 2022: Predicting the future to get ahead of viruses

Feb. 17, 2022
By Anette Breindl
No Comments
Broadly neutralizing antibodies are one of the most powerful weapons against HIV. And like everything that is effective in the fight against HIV, they are hard to come by.
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Global vaccine.png
CROI 2022

Still no HIV vaccine, but optimism fueled by ‘amazing’ science, ‘astounding’ technology

Feb. 16, 2022
By Anette Breindl
No Comments
Barely more than two years into the COVID-19 pandemic, there are five approved vaccines against SARS-CoV-2 available in the U.S. Forty years into the HIV pandemic, there are none. That contrast was repeatedly made by speakers at the 2022 Conference on Retroviruses and Opportunistic Infections (CROI).
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Ebola virus

Persistent Ebolavirus in brain seeds relapses

Feb. 16, 2022
By W. Todd Penberthy
No Comments
In the Feb. 9, 2022, issue of Science Translational Medicine, investigators reported the anatomical location in which the Ebola virus was hiding and persisting in nonhuman primates had otherwise appeared to have been cured by monoclonal therapy prior to the relapse.
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HIV infected cell

CROI 2022: HIV remission – with transplant, without GVHD – brings hope and insights

Feb. 15, 2022
By Anette Breindl
No Comments
At the 2022 Conference on Retroviruses and Opportunistic Infections (CROI), investigators reported on a fourth patient who has achieved HIV remission after a stem cell transplant. The patient is the first woman and the first mixed-race person to achieve HIV remission through a transplant procedure. In 2017, she was transplanted with cord blood stem cells lacking a functional CCR5 receptor, which prevents HIV from entering cells.
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COVID-19 research illustration

Studies at CROI show interferons' complex effects, therapeutic potential

Feb. 15, 2022
By Anette Breindl
No Comments
It's neither a retrovirus nor an opportunistic infection. But of course, SARS-CoV-2 has a prominent place at the table at the 2022 Conference on Retroviruses and Opportunistic Infections (CROI) – starting with the fact that COVID-19 has again forced the conference to go virtual.
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Microscope image of SARS-CoV-2

T-cell evasion is one pressure shaping SARS-CoV-2 evolution

Feb. 14, 2022
By Nuala Moran
No Comments
The overwhelming focus of research into the cellular immune response to SARS-CoV-2 has been investigating the reaction of vaccinated people, in an effort to establish correlates of protection required to fight off infection. But with a majority in many African and Asian countries still unvaccinated, it also is important to understand the natural cellular immune response, and to track the emergence of SARS-CoV-2 variants with the potential to escape immunity in these populations.
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