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BioWorld - Wednesday, December 10, 2025
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Illustration of the β2-adrenergic receptor
Endocrine/metabolic

Exercise-mimicking compound offers alternative to GLP-1 therapies

June 27, 2025
By Mar de Miguel
No Comments
An experimental drug for treating diabetes and obesity has been shown to lower blood sugar levels and increase fat burning. It is a β2-adrenergic receptor (β2AR) agonist that mimics the effects of physical exercise by activating skeletal muscle metabolism. Unlike GLP-1-based treatments such as semaglutide and tirzepatide, this new compound, developed by researchers at the Karolinska Institute, Stockholm University, and the biotech company Atrogi AB, does not suppress appetite or cause muscle loss. 
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Multiple sclerosis
Neurology/psychiatric

At EAN 2025, DEI Hub launches to improve care for all

June 26, 2025
By Anette Breindl
No Comments
In recognition of the fact that diversity, equity and inclusion are necessary prerequisites for precision medicine, the European Academy of Neurology announced the launch of a DEI Hub at its 11th Congress, which is being held in Helsinki through June 24.
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3D rendering of CAR T therapy in cell
Neurology/psychiatric

EAN 2025: CAR T cells take on neurological disorders

June 25, 2025
By Anette Breindl
No Comments
At the 11th Congress of the European Academy of Neurology, which was held in Helsinki June 21 to June 24, researchers presented new data on using CAR T cells in autoimmune neurological conditions.
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3D rendering of CAR T therapy in cell
Neurology/psychiatric

EAN 2025: CAR T cells take on neurological disorders, though sometimes still one patient at a time

June 25, 2025
By Anette Breindl
No Comments
At the 11th Congress of the European Academy of Neurology, which was held in Helsinki June 21 to June 24, researchers presented new data on using CAR T cells in autoimmune neurological conditions.
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3D rendering of CAR T therapy in cell
EAN 2025

CAR T cells take on neurological disorders, though sometimes still one patient at a time

June 24, 2025
By Anette Breindl
No Comments
At the 11th Congress European Academy of Neurology, which was held in Helsinki June 21 to June 24, researchers presented new data on using CAR T cells in autoimmune neurological conditions.
Read More
Multiple sclerosis
Neurology/psychiatric

At EAN 2025, DEI Hub launches to improve care for all

June 23, 2025
By Anette Breindl
No Comments
In recognition of the fact that diversity, equity and inclusion (DEI) are necessary prerequisites for precision medicine, the European Academy of Neurology (EAN) announced the launch of a DEI Hub at its 11th Congress, which is being held in Helsinki through June 24. “We know now that when we talk about personalized medicine, we have to understand that talking about stroke, for example, in a woman is different than talking about stroke in a man,” EAN president Elena Moro told the audience at the opening session of the conference.
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3D illustration of a chain of amino acid or biomolecules called protein
Drug design, drug delivery & technologies

Alphadesign: AI creating proteins from scratch

June 19, 2025
By Nuala Moran
No Comments
The Alphafold machine learning system for predicting a protein’s structure from its amino acid sequence has been adapted to make it possible to design de novo proteins that fold in a particular way and bind to prespecified target proteins. The sister system, called Alphadesign, works by generating random strings of amino acids, using Alphafold to predict their structure, and then iteratively optimizing the design.
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3D illustration of a chain of amino acid or biomolecules called protein

Alphadesign: AI creating proteins from scratch

June 17, 2025
By Nuala Moran
No Comments
The Alphafold machine learning system for predicting a protein’s structure from its amino acid sequence has been adapted to make it possible to design de novo proteins that fold in a particular way and bind to prespecified target proteins. The sister system, called Alphadesign, works by generating random strings of amino acids, using Alphafold to predict their structure, and then iteratively optimizing the design.
Read More
Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 13, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions.
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Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 11, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions to analyze the microbiome differences and their effects after transplantation form different intestine areas. The results show how host-microbe mismatches after these interventions could affect gut health.
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