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Brain samples of people with APOE3/4 vs. APOE3/3
Neurology/Psychiatric

APOE4 allele reduces myelination in Alzheimer’s disease

Nov. 16, 2022
By Mar de Miguel
Carrying the apolipoprotein E4 allele (APOE4), and not the APOE3 variant, is the strongest risk factor for developing Alzheimer’s disease (AD). But the underlying mechanism has remained elusive. Now, researchers at MIT and Mount Sinai have found that in brains carrying the APOE4 allele, lipid and cholesterol processes were dysregulated in oligodendrocytes and that this effect reduced myelination.
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Mitochondria long way from the nucleus and in need of closer sources of proteins
Neurology/Psychiatric

Neuroscience 2022: ‘Strawberries’, ‘cabbages,’ fats in neuronal mitochondria

Nov. 15, 2022
By Mar de Miguel
Neurons are specialized cells with a high metabolic demand to fulfill their function, survive or keep a healthy half-life. In this sense, the anabolism and catabolism of proteins and lipids could be associated to different neurodegenerative diseases. At the 2022 annual meeting of the Society for Neuroscience, scientists reported the latest discoveries on neuron metabolic needs at a session on 'Powering Thoughts: The Regulation of Neuronal Energy Metabolism and Mitochondria.'
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Killer T cells (green and red) surround a cancer cell (blues)
SITC 2022

Business is shaky, but science is groundbreaking for engineered T-cell study

Nov. 11, 2022
By Anette Breindl
In August, Pact Pharma Inc. suspended its phase I trial after 16 patients had been treated with its autologous CRISPR-edited T cells “for business reasons,” the company announced at the time. Scientifically, though, the trial broke enough new ground to be concurrently presented in a late-breaking oral session at the 2022 annual meeting of the Society for the Immunotherapy of Cancer (SITC) and published as an accelerated article preview in Nature on Nov. 10, 2022.
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Magnetic bacteria

Magnetic attraction makes bacteria better drug delivery vehicles

Nov. 9, 2022
By Nuala Moran
A new method for controlling naturally magnetized bacteria has improved the prospects of applying them as vehicles for intratumoral delivery of cancer drugs and in hyperthermia therapy.
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Liver illustration

At AASLD 2022, polygenic risk score subtypes NAFLD

Nov. 7, 2022
By Anette Breindl
Modern molecular techniques have progressed to the point where sequencing can seem almost quaint. At the Basic Science Symposium of The Liver Meeting 2022, new techniques were on full display, with sessions devoted to epigenetics, microbiome analysis and spatial transcriptomics. But the first session was still on genetic variants in all their forms – rare variants, common variants and non-germline mutations.
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Brain illustration

‘On-demand’ epilepsy gene therapy selectively calms hyperactive cells

Nov. 4, 2022
By Anette Breindl
By pairing the expression of an inhibitory ion channel with an activity-dependent promoter, researchers have developed the first on-demand gene therapy that specifically silenced hyperactive cells and prevented epileptic seizures.
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Brain illustration

‘On-demand’ epilepsy gene therapy selectively calms hyperactive cells

Nov. 3, 2022
By Anette Breindl
By pairing the expression of an inhibitory ion channel with an activity-dependent promoter, researchers have developed the first on-demand gene therapy that specifically silenced hyperactive cells and prevented epileptic seizures.
Read More
The Combat of Rama and Ravana.
Cancer

ENA 2022: Mutant specific or target selective, that is the question for drug development

Nov. 1, 2022
By Mar de Miguel and Anette Breindl
Diwali, the Festival of Light, marks different events depending on where it is celebrated. In some areas of India, it marks the return of Lord Rama to his birthplace of Ayodhya after defeating the demon Ravana.
Read More
The Combat of Rama and Ravana.
Cancer

ENA 2022: Mutant specific or target selective, that is the question for drug development

Oct. 27, 2022
By Mar de Miguel and Anette Breindl
Diwali, the Festival of Light, marks different events depending on where it is celebrated. In some areas of India, it marks the return of Lord Rama to his birthplace of Ayodhya after defeating the demon Ravana. For Vivek Subbiah, associate professor at the Department of Investigational Cancer Therapeutics, Division of Cancer Medicine of the MD Anderson Cancer Center, the story of how Rama defeated Ravana has parallels in drug discovery. Ravana had 10 heads, and when one was cut off, it grew back. Rama defeated Ravana by means of a magic arrow that entered through the demon’s navel.
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Brain mapping illustration

Precision psychiatry, marching to the beat of its own drummer

Oct. 25, 2022
By Anette Breindl
There is little doubt that progress in many brain diseases is being hampered because many, maybe most, diagnostic categories do not reflect underlying brain processes. In other disease areas, modern genetic and genomic methods have arrived in the form of approved drugs, from KRAS inhibitors in cancer to PCSK9 inhibitors to lower cholesterol. But brain diseases are different. Psychiatry is simultaneously the most personal area of medicine, and the least precise.
Read More
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