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Home » Topics » Cell therapy » CAR T

CAR T
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3D illustration of T cells fighting cancer
Newco news

Immunoscape to develop new, safe TCR therapies for solid tumors

March 12, 2024
By Marian (YoonJee) Chu
Seven years since the first approval of two chimeric antigen receptor T-cell therapies for hematological cancers, U.S. and Singapore-based Immunoscape Pte Ltd. is looking to develop novel T-cell receptor (TCR) therapeutics for solid tumors.
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3D illustration of T cells fighting cancer
Newco news

Immunoscape to develop new, safe TCR therapies for solid tumors

March 7, 2024
By Marian (YoonJee) Chu
Seven years since the first approval of two chimeric antigen receptor T-cell therapies for hematological cancers, U.S. and Singapore-based Immunoscape Pte Ltd. is looking to develop novel T-cell receptor (TCR) therapeutics for solid tumors.
Read More
Co-culture that shows the CAR T-cell clusters attacking the tumor cells (in green)
Immuno-oncology

TYRP1 CAR T-cell therapy shows activity in models of melanoma

Feb. 22, 2024
Researchers from University of California Los Angeles and affiliated organizations published data from a study that aimed to identify novel surface proteins that are highly and selectively expressed in tumors and could serve as targets for chimeric antigen receptor (CAR) T-cell therapies for the treatment of melanoma.
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CAR T cells attacking cancer cell
Drug Design, Drug Delivery & Technologies

Enhancing CAR T cells with degraders and ligases

Dec. 1, 2023
By Mar de Miguel
Researchers have developed a new approach for the development of improved CAR T cells with bifunctional degraders, which linked ubiquitin to an endogenous target protein. The key to the design was the use of multispecific protein degraders and E3 ligases, which increased the proliferation of CAR T cells and their antitumor potency. This combination can be adapted to different uses of cell therapies.
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CAR T cells attacking cancer cell

Legend signs $1B T-cell therapy deal with Novartis

Nov. 14, 2023
By Lee Landenberger
Legend Biotech Corp. is entering what it no doubt hopes will be another fruitful collaboration with big pharma. Legend’s wholly owned subsidiary, Legend Biotech Ireland Ltd., will work with Novartis AG in an exclusive global development and license agreement for chimeric antigen receptor T-cell therapies targeting DLL3.
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CAR T cells attacking cancer cell

Legend signs $1B T-cell therapy deal with Novartis

Nov. 13, 2023
By Lee Landenberger
Legend Biotech Corp. is entering what it no doubt hopes will be another fruitful collaboration with big pharma. Legend’s wholly owned subsidiary, Legend Biotech Ireland Ltd., will work with Novartis AG in an exclusive global development and license agreement for chimeric antigen receptor T-cell therapies targeting DLL3.
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Immuno-oncology

Coimmune exercises option to target DLL3 with IL-18 armored CAR technology under MSK agreement

June 28, 2023
Coimmune Inc. has obtained a license to target delta-like ligand 3 (DLL3) with IL-18 armored chimeric antigen receptor (CAR) technology. The company exercised an option to obtain an exclusive license in the DLL3-targeted, allogeneic CAR-cytokine induced killer (CAR-CIK) cell therapy field to IL-18 armored CAR technology under an agreement with Memorial Sloan Kettering Cancer Center (MSK).
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Immuno-oncology

EHA 2023: IF they work, logic-gated CAR T cells could work BETTER for complex targeting

June 13, 2023
By Anette Breindl
Part of the reason for CAR T cells’ astonishing success in B-cell cancers is that B cells are astonishingly easy to replace. CAR T cells are specific, yes. But they are not specific to tumor cells. They are specific to their target antigens. In the case of Yescarta (axicabtagene ciloleucel, Gilead Sciences Inc.) and Kymriah (tisagenlecleucel, Novartis AG), the first two clinically approved T cells, that target is CD19, which is expressed on B-cell precursors. And when it is successful, the treatment leaves patients without any B cells at all.
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Immune

Genetically engineered β cells evade autoimmunity in type 1 diabetes model

April 19, 2023
By Subhasree Nag
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the person’s immune system destroys its own pancreatic islet cells that leads to complete loss of insulin production. Allogeneic pancreatic islet cell transplantation has been shown to replenish the vanished β-cell population and provide glycemic control, restoration of hypoglycemia awareness, and protection from severe hypoglycemic events. However, with allogeneic transplantation, there is a need for life-long immunosuppression to protect the islet grafts from allo- and autoimmunity.
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Immuno-oncology

Preclinically optimized CAR T-cell therapy targeting glypican-2 shows efficacy against neuroblastoma

Feb. 21, 2023
Over half of the children with high-risk neuroblastoma experience late relapses caused by minimal residual disease. Since chimeric antigen receptor (CAR) T-cell therapy has shown efficacy against minimal residual disease in pediatric patients with hematologic malignancies, several CAR T-cell therapies are being investigated for neuroblastoma.
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