Breast cancer-associated gene 1 (BRCA1) is a critical tumor suppressor in breast cancer, and BRCA1 deficiency impairs DNA damage repair, leading to DNA damage accumulation and subsequent genetic alterations that result in the onset of breast cancer. In the current study, researchers from the University of Macau aimed to identify the potential factors that may participate in BRCA1-associated tumorigenesis.

Primary sclerosing cholangitis (PSC) is a disease affecting the bile ducts that can lead to end-stage liver disease and cholangiocarcinoma. Patients with this disease lack therapeutic treatment other than liver transplantation.

Investigators at the University of Copenhagen and affiliated organizations presented data from a study that aimed to validate differentially expressed genes (DEGs) in mesial temporal lobe epilepsy (mTLE) as potential new targets.

Researchers from University Hospital and University of Zürich aimed to assess the effects of serotonin on the tumor microenvironment.

Researchers from University College Dublin and affiliated organizations presented data from a study that aimed to assess the role of α-melanocyte-stimulatory hormone (α-MSH) in diabetes.

Scientists at Surface Oncology Inc. described data from a study that aimed to evaluate the role of IL-27, a heterodimeric cytokine that plays a role in controlling the intensity and duration of immune system responses, in cancer therapy resistance.

Researchers have designed a 3D model of lung cancer that is composed of bronchial epithelial, fibroblasts, epithelial, lung adenocarcinoma and immune cells grown in different layers in a matrigel.