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Home » Topics » Science » Targeted therapy

Targeted therapy
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Immuno-oncology

MC5R antagonism enhances tumor immunity in ICT-resistant cancers

Sep. 13, 2022
Previous research has revealed that some downstream hormones or effectors of the hypothalamic-pituitary (HP) unit, such as glucocorticoids, estrogen and progesterone, are elevated in patients with cancer. It was also shown that these hormones regulate the function of immune cells in the tumor microenvironment, suggesting that the neuroendocrine system and HP unit might modulate tumor immunity. In the current study, researchers from the University of Science and Technology of China aimed to investigate the role of HP unit in tumor immunity.
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Skin irritation on hands
Dermatologic

HY-209: a GPCR19 agonist inhibiting NLRP3 inflammasome activation as a potential therapeutic for atopic dermatitis

Sep. 13, 2022
Researchers from Shaperon Inc. presented positive preclinical data for their clinical-stage candidate, sodium taurodeoxycholate (HY-209), demonstrating its therapeutic potential for atopic dermatitis.
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AACR Virtual Meeting II

Resistance to targeted therapies: It works until it doesn't

June 24, 2020
By Brian Orelli
Targeted therapy offers an opportunity for personalized medicine that's specific for a patient's tumor, but the hyper-focused treatment creates possibilities for cells to mutate and become resistant to the therapy.
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Even in mutated oncogenes, tissue of origin matters

July 11, 2019
By Nuala Moran
Despite the arrival of FDA-approved tissue-agnostic targeted cancer therapies, there is increasing recognition that the response of tumors that are driven by the same oncogene differs according to their location.
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Beyond Warburg, other tumor metabolism aspects are ripe for targeting

July 2, 2019
By Anette Breindl
The Warburg effect – the marked preference of tumors for fueling themselves via anaerobic metabolism – was described more than 90 years ago. Otto Warburg won the Nobel Prize for his discovery in 1931, and research into the phenomenon long dominated the field of tumor metabolism. Over the past decade, however, there has been increased attention to the fact that tumor metabolism is deregulated in multiple ways beyond the Warburg effect.
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