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BioWorld - Sunday, May 22, 2022
Home » Topics » Clinical

Clinical
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T cells

TIGIT-al camera snapshot shows cancer bids fill the frame

Feb. 27, 2020
By Randy Osborne
No Comments
During a recent investor event related to early drug development, Basel, Switzerland-based Roche Holding AG touted research by the firm’s Genentech unit into the cancer target known as TIGIT, or T-cell immunoreceptor with Ig and ITIM domains, and the pharma giant is hardly alone in the sizzling space.
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Kadmon TCT data provide ‘Incyte,’ GVHD odds looking better

Feb. 27, 2020
By Randy Osborne
No Comments
New York-based Kadmon Holdings Inc.’s recent oral late-breaker session on KD-025 in chronic graft-vs.-host disease (cGVHD) at the Transplantation & Cellular Therapy (TCT) meeting – along with data that rolled out from two studies testing competitor Jakafi (ruxolitinib) from Incyte Corp. – signaled potential advantages in the former’s candidate, already highly regarded.
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Small study finds AI gets patients to stroke treatment faster, as 500-patient study to start

Feb. 26, 2020
By Stacy Lawrence
No Comments
Artificial intelligence still has a lot to prove when it comes to its relevance in improving health care. But one bright spot was a deal last July between Dublin-based Medtronic plc and San Francisco-based startup Viz.ai Inc. to use the latter’s AI system that’s designed to spot a large vessel occlusion automatically in CT angiogram images.
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Menlo, Vanda see mixed results after missing primary endpoints in pruritus trials

Feb. 26, 2020
By Michael Fitzhugh
No Comments
Readouts from two ambitious pruritus trials this week yielded starkly different reactions from investors seeking broader meaning in the outcomes.
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Nevro shines following quarterly results, positive news on NSRBP study

Feb. 26, 2020
By Liz Hollis
No Comments
Nevro Corp.’s stock was up following encouraging results detailed during its fourth-quarter earnings call. Management predicted a positive 2020, highlighting the potential of the U.S. spinal cord stimulation (SCS) market. Keith Grossman, chair, CEO and president of the company, noted that the SCS market slowed last year as a result of stocking issues – a challenge that affected both it and its competitors.
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Architectural pillars

Judge orders HHS to fill 10-year data gap on Clinicaltrials.gov

Feb. 26, 2020
By Mari Serebrov
No Comments
While the staff at the U.S. Department of Health and Human Services (HHS) is currently all hands-on-deck in responding to the COVID-19 outbreak, some of the agencies in the department may have to divert resources to get sponsors of drug and device clinical trials to fill in nearly a decade-long data gap on Clinicaltrials.gov. That’s if a judge’s decision handed down this week stands.
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Immutep reports positive interim phase II results in Keytruda combo basket trial

Feb. 26, 2020
By Tamra Sami
No Comments
PERTH, Australia – Sydney-based Immutep Ltd. reported positive interim data for its phase II basket trial in non-small-cell lung cancer (NSCLC) and head and neck squamous cell carcinoma for its lead immunotherapy in combination with Merck & Co. Inc.’s anti-PD-1 therapy, Keytruda (pembrolizumab).
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Shock away? Adrenomed’s adrecizumab hits phase II endpoint in septic shock

Feb. 26, 2020
By Cormac Sheridan
No Comments
DUBLIN – Adrenomed AG disclosed Feb. 21 that its first-in-class antibody, adrecizumab, hit the primary safety and tolerability endpoint of a phase II trial in septic shock.
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IMV’s phase II ovarian cancer data trend positive while the stock reverses

Feb. 25, 2020
By Lee Landenberger
No Comments
Updated results from IMV Inc.’s ongoing phase II trial of DPX-Survivac to treat advanced recurrent ovarian cancer show the company’s lead candidate was active and well-tolerated in patients.
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CRT20

Data underscores benefits of Biotronik’s ultrathin strut Orsiro DES

Feb. 25, 2020
By Meg Bryant
No Comments
NATIONAL HARBOR, Md. – Berlin-based Biotronik SE & Co. reported new data from the BIOFLOW-V trial showing that its Orsiro ultrathin strut drug-eluting stent (DES) continued to outperform Abbott Laboratories’ Xience DES through three years’ follow-up.
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