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BioWorld - Wednesday, April 15, 2026
Home » Topics » Clinical

Clinical
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Onzeald to potter’s field, Nektar bempeg plans revealed

March 6, 2020
By Randy Osborne
During its Feb. 27, 2020, conference call on the previous year’s fourth-quarter results – though not in a related press release – Nektar Therapeutics Inc. let news drop that the prospective breast cancer (BC) therapy Onzeald (etirinotecan pegol) for patients with brain metastases had failed in top-line phase III outcomes.
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Physiq AI platform gives advance notice of up to 10 days of impending heart failure crisis

March 4, 2020
By Annette Boyle
An artificial intelligence (AI) platform developed by Naperville, Ill.-based Physiq Inc. gave researchers a mean of 10.4 days warning of an impending heart failure exacerbation that would require hospitalization or an emergency department visit, according to a study published in Circulation – Heart Failure.
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Gene editing illustration

Editas, Allergan see first patient dosed with CRISPR candidate for LCA10

March 4, 2020
By Michael Fitzhugh
An experimental gene editing therapy for an inherited form of blindness has become the first in vivo CRISPR medicine to be administered to patients, according to Editas Medicine Inc. and its partner, Allergan plc, which licensed the candidate in 2018.
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Sihuan starts clinical trial of Ebola drug favipiravir for COVID-19

March 4, 2020
By Elise Mak
BEIJING – Beijing-based Sihuan Pharmaceutical Holdings Group Ltd. said it has initiated clinical trials of broad-spectrum antiviral favipiravir to treat COVID-19. China now has six clinical trials investigating the drug, originally developed for influenza and also tested against Ebola virus disease.
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Immutep reports positive interim phase II results in Keytruda combo basket trial

March 3, 2020
By Tamra Sami
PERTH, Australia – Immutep Ltd. reported positive interim data for its phase II basket trial in non-small-cell lung cancer and head and neck squamous cell carcinoma for its lead immunotherapy in combination with Merck & Co. Inc.’s Keytruda (pembrolizumab).
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Rays of light beaming from eye

After some trying times, AGTC ‘night star’ on the rise in XLRP and beyond

March 3, 2020
By Randy Osborne
Strongly favorable six-month data disclosed on Jan. 9 by Applied Genetic Technologies Corp. (AGTC) from its ongoing phase I/II program with an adeno-associated virus (AAV) gene therapy for X-linked retinitis pigmentosa (XLRP) did more than provide a whopping stock boost.


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Cool beans: Boston phase III exportin success to broader Xpovio label?

March 3, 2020
By Randy Osborne
With new phase III multiple myeloma (MM) data in hand from Newton, Mass.-based Karyopharm Therapeutics Inc.’s Xpovio (selinexor), Wall Street began speculating about what the results might mean in the marketplace.
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Cancer cell, DNA illustration

Todos Medical sets sights on COVID-19 test market

March 2, 2020
By Meg Bryant
New York and Rehovot, Israel-based in vitro diagnostics startup Todos Medical Ltd. is developing blood tests for the early detection of cancer and neurodegenerative diseases using Fourier-transform infrared (FTIR) spectroscopy. Now the company is looking to apply the technology in diagnosing infections, including the novel coronavirus, COVID-19.
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Diabetes tech use still limited, but the latest data aims to broaden CGM, closed loop reach

Feb. 28, 2020
By Stacy Lawrence
Over the last few years, Wall Street has fervently embraced the largest diabetes technology companies, particularly those behind continuous glucose monitors, insulin pumps, and the automated closed loop systems that incorporate both to work together.
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Livanova teams up with Verily on depression trial

Feb. 27, 2020
By Meg Bryant
London-based Livanova plc has entered a collaboration with Verily Inc., an Alphabet company, to enrich data from its RECOVER trial using tools and analytics developed by Verily. The study, which kicked off last September, is assessing the effectiveness of vagus nerve stimulation (VNS) therapy for patients with difficult-to-treat depression (DTD).
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