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BioWorld - Thursday, January 8, 2026
Home » Topics » Clinical

Clinical
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Illustration of neurons with Lewy bodies

Enhanced Cognition: Lewy body dementia phase II pumps stock

Dec. 18, 2024
By Randy Osborne
Investors will get more details during the International Lewy Body Dementia Conference in Amsterdam late next month, but Wall Street is already buzzing about Cognition Therapeutics Inc.’s data from the phase II study with CT-1812 in dementia with Lewy bodies.
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Freed from clinical hold, Biomea’s menin inhibitor solid in T2D

Dec. 17, 2024
By Lee Landenberger
Released from a clinical hold by the U.S. FDA in late September, Biomea Fusion Inc.’s menin inhibitor, icovamenib, has charged ahead to produce positive top-line data from a phase II study in type 2 diabetes (T2D). The data, however, didn’t stop the stock from dropping to near its lowest level of the past 12 months.
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Acute myeloid leukemia
ASH 2024

Kura, Kyowa highlight positive combo data for ziftomenib

Dec. 17, 2024
By Tamra Sami
Kura Oncology, Inc. and Kyowa Kirin Co. Ltd.’s selective oral menin inhibitor ziftomenib showed encouraging data across multiple studies, the most encouraging of which were in combination with other standard of care therapies in patients with NPM1-mutant and KMT2A-rearranged  acute myeloid leukemia.
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SK Bioscience scientist in lab

SK Bioscience to start mRNA vax trial for Japanese encephalitis

Dec. 17, 2024
By Marian (YoonJee) Chu
SK Bioscience Co. Ltd. gained approval from the Human Research Ethics Committee in Australia to start phase I/II trials of GBP-560, its mRNA-based vaccine candidate for mosquito-borne Japanese encephalitis virus, with funding from Coalition for Epidemic Preparedness Innovations.
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Synthetic antibiotic Recce-327

Recce moves to pivotal trials in Indonesia for diabetic foot ulcers

Dec. 17, 2024
By Tamra Sami
Recce Pharmaceuticals Ltd. is progressing synthetic antibiotic Recce-327 to pivotal phase III trials in Indonesia for the treatment of diabetic foot infections. The trial, which is assessing Recce-327 as a topical gel (R327G), is expected to begin in the first quarter of 2025, Recce CEO James Graham told BioWorld.
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Man measuring waist

Caliway’s CBL-514 meets endpoints in reducing abdominal fat

Dec. 17, 2024
By Tamra Sami
Caliway Biopharmaceuticals’ lipolysis candidate, CBL-514, met all the primary and secondary efficacy endpoints in a phase IIb study for subcutaneous fat reduction, paving the way for the company to begin a global pivotal phase III study in 2025.
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Happier new year? Tenaya to raise HCM gene therapy dose

Dec. 17, 2024
By Randy Osborne
Wall Street must wait until 2025 for data from the higher-dose cohort in Tenaya Therapeutics Inc.’s phase Ib/II study with gene therapy TN-201 for MYBPC3-linked hypertrophic cardiomyopathy (HCM), but shares (NASDAQ:TNYA) closed Dec. 17 at $1.41, down $1.47, or 51%, after results from the first cohort rolled out.
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Illustration for inflammatory bowel disease

Teva-Sanofi upbeat on ‘best-in-class’ duvakitug bowel disease data

Dec. 17, 2024
By Karen Carey
The potential for TL1A-targeting duvakitug to impact unmet needs of patients with ulcerative colitis (UC) and Crohn’s disease (CD), and to provide antifibrotic effects for a host of other diseases, boosted shares of Teva Pharmaceutical Industries Ltd. and Sanofi SA by 26.5% and 6.7%, respectively, as the partners released what analysts called “best-in-class” results from the phase IIb Relieve UCCD study and prepare for a phase III trial in 2025.
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Synthetic antibiotic Recce-327

Recce moves to pivotal trials in Indonesia for diabetic foot ulcers

Dec. 16, 2024
By Tamra Sami
Recce Pharmaceuticals Ltd. is progressing synthetic antibiotic Recce-327 to pivotal phase III trials in Indonesia for the treatment of diabetic foot infections. The trial, which is assessing Recce-327 as a topical gel (R327G), is expected to begin in the first quarter of 2025, Recce CEO James Graham told BioWorld.
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Puretech’s modified pirfenidone impresses in phase IIb IPF trial

Dec. 16, 2024
By Nuala Moran
Puretech Health plc has announced phase IIb data showing its reformulation of pirfenidone has improved the tolerability and increased the efficacy of the marketed antifibrotic in the treatment of idiopathic pulmonary fibrosis. The tweak on the original molecule involved substituting three hydrogen atoms with three of the heavier counterpart, deuterium, improving stability, whilst retaining the antifibrotic effect.
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