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Home » Topics » Clinical

Clinical
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Elderly woman holding illustration of brain with missing puzzle piece

As diagnostics advance, Parkinson’s sector waits for better therapy

June 8, 2023
By Randy Osborne
Standing as one of the more prominent among incurable conditions, Parkinson’s disease (PD) still hasn’t met a medicine or surgical intervention that can slow or stop progression, despite efforts of many drug developers testing new strategies.
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Fibrogen down on second phase III failure in a month

June 7, 2023
By Karen Carey
It has been a tough spring for Fibrogen Inc., which reported another phase III miss on June 7, this time for rare disease drug pamrevlumab to treat non-ambulatory patients with Duchenne muscular dystrophy (DMD).
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Elderly woman holding illustration of brain with missing puzzle piece

As diagnostics advance, Parkinson’s sector waits for better therapy

June 7, 2023
By Randy Osborne
Standing as one of the more prominent among incurable conditions, Parkinson’s disease (PD) still hasn’t met a medicine or surgical intervention that can slow or stop progression, despite efforts of many drug developers testing new strategies.
Read More
DNA sequencing
ASCO 2023

Galleri showcases Grail’s MCED technology in real-world setting

June 6, 2023
By Annette Boyle
In the flurry of presentations on early detection of cancer at the 2023 American Society of Clinical Oncology Annual Meeting, Grail LLC stood out for the number of sessions and the strength of its results. In a real-world study presented, Grail’s Galleri multi-cancer early detection (MCED) test cancer signal origin (CSO) demonstrated accuracy of 91%.
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ASCO 2023: Toripalimab extends OS, final phase III trial data show

June 6, 2023
By Caroline Richards
When combined with chemotherapy, the PD-1 inhibitor antibody toripalimab reduced the risk of death by 37% over chemotherapy alone when used first line in patients with recurrent or metastatic nasopharyngeal carcinoma, Coherus Biosciences Inc. revealed at this year’s American Society of Clinical Oncology meeting (ASCO).
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Maintenance phase II data offer boost to Connect’s partnering plans for UC drug

June 6, 2023
By Jennifer Boggs
Additional data from a phase II trial of S1P modulator icanbelimod (CBP-307) reinforced earlier positive results in ulcerative colitis (UC), potentially putting Connect Biopharma Holdings Ltd. in a better negotiating position as it seeks a partner to take the program forward, while in-house activities remain focused on an early 2024 regulatory filing for atopic dermatitis candidate CBP-201.
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William Cao, founder and CEO, Gracell Biotechnologies

Gracell enters autoimmune space with its dual-targeting CAR T

June 6, 2023
By Tamra Sami
Gracell Biotechnologies Inc. is initiating two clinical trials in China in refractory systemic lupus erythematosus for lead candidate GC-012F, a CD19/B-cell maturation antigen dual-targeting CAR T. 
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Microblate Flex device

Creo’s Microblate Flex poised to provide early lung cancer detection

June 5, 2023
By Nuala Moran
Creo Medical Group plc says it is poised to address the mismatch between the advances in screening technology, which are making it possible to detect early-stage lung cancer, and the current invasive and inappropriate methods of treating it, following the first-in-human use of its Microblate Flex microwave ablation device.
Read More
Brain clay model

ASCO 2023: Day One on a roll with NDA, updated pediatric glioma data

June 5, 2023
By Jennifer Boggs
Impressive data continue to roll out for Day One Biopharmaceuticals Inc.’s tovorafenib in pediatric low-grade glioma, with results from 69 evaluable patients with relapsed or progressive disease showing a 67% overall response rate, as measured by Response Assessment for Neuro-Oncology High-Grade Glioma, in the phase II Firefly-1 trial.
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Breast cancer illustration

ASCO 2023: Novartis and Lilly make progress in early breast cancer treatments

June 5, 2023
By Lee Landenberger
Positive data from two studies treating early breast cancer with CDK4/6 inhibitors presented at the American Society of Clinical Oncology (ASCO) meeting in Chicago showed progress is helping patients live longer. The two treatments and companies, Novartis AG and Eli Lilly and Co., are nearly head-to-head competitors in the niche indication.
Read More
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