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Home » Topics » Clinical

Clinical
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Green traffic light

Aprinoia gets NMPA nod for PET imaging tracer 18F-APN-1607 phase III trials in China

Nov. 3, 2020
By Gina Lee
HONG KONG – Aprinoia Therapeutics Inc. is poised to start phase III clinical trials for its positron emission tomography (PET) imaging tracer 18F-APN-1607 in China, after receiving the green light from the National Medical Products Administration.
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NBTXR3 vials

Nanobiotix's novel radioenhancer shows strong early results in multiple cancers

Nov. 3, 2020
By Annette Boyle
Nanobiotix SA ’s achieved promising early results in several clinical trials for its first-in-class radioenhancer. Despite the pandemic, trials in head and neck squamous cell cancer, hepatocellular carcinoma, pancreatic cancer, and rectal cancer remain on track, the Cambridge, Mass., and Paris-based company reported at ASTRO 2020.
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Few tears for failure of Aurinia's voclosporin solution trial in dry eye disease

Nov. 3, 2020
By Michael Fitzhugh
Aurinia Pharmaceuticals Inc. is suspending further development of voclosporin ophthalmic solution (VOS) for dry eye syndrome after a dose-ranging trial of the candidate failed to meet its primary endpoint of improving a measure of the condition after four weeks of treatment.
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SEAL of approval: Karyopharm’s phase III hits primary endpoint in liposarcoma

Nov. 3, 2020
By Lee Landenberger
Karyopharm Therapeutics Inc. posted positive top-line results from the phase III SEAL trial of Xpovio (selinexor), including meeting the study’s primary endpoint, and likely extending its reach into the company’s bottom line.
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BMS’s deucravacitinib bests Otezla in psoriasis

Nov. 3, 2020
By Cormac Sheridan
Bristol Myers Squibb Co. reported that its first-in-class oral selective kinase 2 inhibitor, deucravacitinib (formerly BMS-986165), beat out Otezla (apremilast) in a head-to-head phase III trial in psoriasis.
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In the clinic for Nov. 3, 2020

Nov. 3, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: ADC, Adial, Aptevo, Aurinia, Biogen, BMS, Celltrion, Concert, Edesa, GW, Horizon, Karyopharm, Lilly, Prometic.
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Antibodies attacking cancer cell

Jounce tumbles as phase II NSCLC trial readout disappoints

Nov. 2, 2020
By Michael Fitzhugh
Jounce Therapeutics Inc. has quit enrolling Emerge, an open-label phase II study of its inducible T-cell co-stimulator agonist, vopratelimab, the company’s most advanced candidate.
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Study shows cellular immunity at six months post COVID-19 infection

Nov. 2, 2020
By Nuala Moran
LONDON – People infected with COVID-19 are likely to have T-cell immunity six months after contracting the virus, according to a U.K. study of 100 subjects who had an asymptomatic or mild to moderate infection.
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In the clinic for Nov. 2, 2020

Nov. 2, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Agenus, Aim, Aivita, Aligos, Arcutis, Astrazeneca, Curevac, Daiichi, Eli Lilly, Gritstone, Humanigen, Immunic, Incyte, Jounce, Mindmed, Novartis, Resverlogix, Revimmune, Rhythm, Shionogi, Sun, Symvivo, Tetra, Tiziana, UCB, Ultimovacs.
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Stem cells

Motix mobilizes Biolinerx shares as late-stage data favors drug

Oct. 30, 2020
By Michael Fitzhugh
An interim analysis of Biolinerx Ltd.'s phase III test of motixafortide for stem cell mobilization in multiple myeloma patients has paved what CEO Philip Serlin called the "most efficient path to registration" for the candidate, an antagonist of the chemokine receptor CXCR4.
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