Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine that has been shown to be involved in metabolic regulation, development of lung disease and support of hematopoiesis, apart from its known roles in the central nervous system. Its plasma levels during sepsis were investigated in this study.
Kirsten rat sarcoma viral oncogene (KRAS) is one of the GTPases from the RAS family activating signaling pathways that regulate cell functions. KRAS mutation of glycine to aspartate at position 12 (G12D) is a common mutation in pancreatic ductal adenocarcinoma, colorectal cancer, lung adenocarcinoma and other solid tumors. ASP-3082 is a proteolysis targeting chimera (PROTAC) under development by Astellas Pharma Inc. The company has presented the first in vitro and in vivo results of this new compound.
Researchers from the University of Saskatchewan have developed a novel theranostic candidate, [67Cu]EB-TATE, as an alternative to [177Lu]DOTATATE, for the imaging of gastroenteropancreatic neuroendocrine tumors (GEP-NET). EB-TATE, which is a derivative of octreotate with evans blue (EB), was radiolabeled with electron linear accelerator-produced 67CuCl2.
Diwali, the Festival of Light, marks different events depending on where it is celebrated. In some areas of India, it marks the return of Lord Rama to his birthplace of Ayodhya after defeating the demon Ravana. For Vivek Subbiah, associate professor at the Department of Investigational Cancer Therapeutics, Division of Cancer Medicine of the MD Anderson Cancer Center, the story of how Rama defeated Ravana has parallels in drug discovery. Ravana had 10 heads, and when one was cut off, it grew back. Rama defeated Ravana by means of a magic arrow that entered through the demon’s navel.
South Korea’s regenerative medicine market is expected to grow from $51 million in 2016 to $320 million by 2026, growing at a compound annual growth rate of 20%, So Ra Park, chair and founder of Korea’s Regenerative Medicine Acceleration Foundation said during the Ausbiotech 2022 conference in Perth, Australia, running Oct. 26 to 28.
Researchers from Qualigen Therapeutics Inc. and University of Louisville presented the discovery and preclinical evaluation of a novel pan-RAS inhibitor...
Reduced expression of nuclear factor erythroid 2-related factor 2 (Nrf2) is observed in humans and animal models of Alzheimer’s disease (AD), with its activation being a promising therapeutic approach.
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