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BioWorld - Friday, May 1, 2026
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

New CDK2 degraders disclosed in Triana Biomedicines patent

Jan. 12, 2026
Triana Biomedicines Inc. has divulged protein/nucleic acid degraders acting as cyclin-dependent kinase 2 (CDK2) degraders reported to be useful for the treatment of cancer.
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3D illustration of cancer in crosshairs
Cancer

ADAR1-i-124 switches on antitumor immunity

Jan. 12, 2026
No Comments
Adenosine deaminase acting on RNA (ADAR) is the enzyme responsible for adenosine-to-inosine (A-to-I) RNA editing, a process essential for regulating how cells respond to double-stranded RNA. ADAR1 generates two isoforms, p150 and p110, with distinct roles in cancer biology. Researchers from the Wistar Institute of Anatomy & Biology reported the preclinical characterization of ADAR1-i-124, an ADAR1 inhibitor designed for the treatment of cancer.
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Cancer

Anti-FGFR1 therapy shows efficacy in colorectal cancer models

Jan. 12, 2026
No Comments
FGFR1 is a receptor tyrosine kinase that drives multiple intracellular signaling pathways involved in tumor cell proliferation, survival and progression. Because these pathways are frequently hyperactivated in colorectal cancer (CRC), FGFR1 represents a biologically relevant therapeutic target, and its inhibition has the potential to simultaneously suppress several oncogenic mechanisms.
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Cancer

New GTPase KRAS inhibitors disclosed in SK Biopharmaceuticals patent

Jan. 12, 2026
SK Biopharmaceuticals Co. Ltd. has divulged GTPase KRAS G12D mutant inhibitors reported to be useful for the treatment of cancer.
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IPO puzzle pieces

Aktis raises $318M in first biopharma IPO of 2026

Jan. 9, 2026
By Jennifer Boggs
No Comments
Radiopharma-focused Aktis Oncology Inc. priced its recently upsized IPO, selling 17.65 million shares at $18 apiece, the high end of its pricing range, raising gross proceeds of $318 million, a hopeful sign that 2026 might signal an opening of the IPO window for biopharma.
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voice sensing patch
Patents

Patent for wearable speech-sensing device filed

Jan. 9, 2026
By Greg Kaplan
Jun Chen, a tenured associate professor of bioengineering at the Samueli School of Engineering at the University of California Los Angeles (UCLA), leads a team developing a speech-sensing wearable patch. The technology translates the intricate muscle movements of the larynx into discernible speech.
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Globe and China flag

China slashes tariffs on some medical devices

Jan. 9, 2026
By Tamra Sami
Beginning Jan. 1, 2026, China will apply provisional import tariff rates lower than the most-favored-nation rates on 935 items, the State Council announced. The move aims to boost collaboration between domestic and international sectors, and to leverage resources of both to expand the supply of high-quality goods.
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Cancer

Hangzhou Polymed Biopharmaceuticals patents new EGFR degradation inducers

Jan. 9, 2026
Hangzhou Polymed Biopharmaceuticals Inc. has disclosed proteolysis targeting chimeric (PROTAC) compounds comprising cereblon (CRBN) ligands covalently bonded to an EGFR del19/Thr790Met/Cys797Ser triple mutant and/or EGFR Leu858Arg/Thr790Met/Cys797Ser triple mutant-targeting moiety through a linker reported to be useful for the treatment of cancer.
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Immuno-oncology

Whitehawk announces IND progress for HWK-007, HWK-016

Jan. 9, 2026
No Comments
Whitehawk Therapeutics Inc. has obtained IND clearance from the FDA for HWK-007, its PTK7-targeted antibody-drug conjugate (ADC).
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Immuno-oncology

A2 Biotherapeutics’ A2B-543 gains IND clearance

Jan. 9, 2026
No Comments
A2 Biotherapeutics Inc. has gained IND clearance from the FDA for A2B-543 for the treatment of germline heterozygous HLA-A*02 adults with recurrent unresectable, locally advanced or metastatic solid tumors.
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