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BioWorld - Saturday, January 24, 2026
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Genfleet Therapeutics patents new MAP4K1 inhibitors

Oct. 28, 2022
Genfleet Therapeutics Inc. has divulged amine-substituted pyridine fused-ring compounds acting as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) inhibitors reported to be useful for the treatment of cancer.
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Immune checkpoint inhibitors illustration of PD-1, CTLA-4 and PD-L1.
Immuno-oncology

FDA approves IND for bifunctional fusion protein SIM-0237

Oct. 28, 2022
Simcere Pharmaceutical Group announced that the FDA has cleared the company’s IND application for SIM-0237 for the treatment of adult patients with advanced solid tumors.
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Mantle cell lymphoma
Cancer

KAN-571 demonstrates efficacy in preclinical models of mantle cell lymphoma

Oct. 28, 2022
Kancera AB has reported new preclinical data for its ROR1 inhibitor KAN-571, being developed for the treatment of mantle cell lymphoma (MCL).
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Immuno-oncology

SYS-6002 receives clinical trial approval in China

Oct. 28, 2022
CSPC Pharmaceutical Group Ltd. announced that the National Medical Products Administration of the People’s Republic of China has granted approval to conduct clinical trials of the company’s antibody-drug conjugate candidate, SYS-6002.
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Cancer

Preclinical studies support use of TAS-1440 in combination with anti-PD-1 antibodies for treatment of immunotherapy-resistant cancer

Oct. 28, 2022
Lysine-specific demethylase 1A (LSD1) is a monoamine oxidase encoded by the KDM1A...
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Cancer

I-0436650, a potent and selective SHP2 allosteric inhibitor for solid tumor treatment

Oct. 28, 2022
Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) is a target for cancer...
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Microscopic view of of high grade urothelial carcinoma of the ureter in a man.
Cancer

FTX-6746, a new PPARG inverse agonist with efficacy in urothelial cancer animal models

Oct. 28, 2022
Luminal molecular subtype represents most advanced urothelial cancer (UC) cases. It is...
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Concept illustration of cell-free circulating tumor DNA.
Diagnostics

ENA 2022: Limitations and expectations for the analysis of ctDNA on liquid biopsies

Oct. 28, 2022
By Mar de Miguel
Nowadays, there are many tools for cancer diagnosis, from imaging techniques to biopsies. In traditional blood tests, liquid biopsy bursts onto the scene as an explosion of possibilities driven by molecular techniques for the detection and sequencing of proteins or genetic material. But specialists are cautious because they know that in liquid biopsies not everything is detected. At the ENA 2022 session “The role of ctDNA in clinical trials,” Marie Morfouace, a translational researcher at the EORTC, presented “ctDNA in clinical trial practice today,” where she described the balance of the possibilities of the liquid biopsy when confronting it with the results in patients offered by the studies published to date.
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Vaccinia virus
Newco news

Startup Vacv emerges with $3M and new oncolytic virus strategy

Oct. 27, 2022
By Nuala Moran
Newco Vacv Biotherapeutics Ltd. has raised $3 million in a seed round to complete preclinical development of next-generation oncolytic viruses that are engineered to overcome previous shortcomings of this modality.
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Cancer

Parenchyma Biotech presents new AhR agonists

Oct. 27, 2022
Parenchyma Biotech Inc. has described aryl hydrocarbon receptor (AhR) agonists reported to be useful for the treatment of cancer and autoimmune disease.
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