Eukaryotic translation initiation factor 2-α kinase 3 (PERK) plays a role in homeostasis maintenance of the mitochondria-associated membrane (MAM), which in turn has an impact on the mitochondrial energy metabolism and structural morphology. To date, there is still controversy regarding the therapeutic effect of activating PERK for ischemia-reperfusion injury (I/R) management.
Although congenital aortic valve disease (AVD) is one of the most prevalent types of congenital heart disease, affecting 1% to 2% of the population, the understanding of the molecular genetics and mechanisms underlying the disease remains limited.
Endoplasmic reticulum oxidoreductase 1 (ERO1) has traditionally been associated with proper protein folding in the endoplasmic reticulum, but it has recently been linked to platelet activation and aggregation in arterial thrombosis and ischemic stroke.
Thoracic aortic dissection can progress to a highly lethal cardiac emergency, but it cannot usually be detected in early stages, so suitable biomarkers of progression are needed. Levels of C-reactive protein in serum rise during progression, but they also rise in infectious or autoimmune conditions, making the biomarker nonspecific.
Foresight Therapeutics (Hefei) Co. Ltd. has prepared and tested new cardiac myosin inhibitors reported to be useful for the treatment of hypertrophic cardiomyopathy.
Researchers have identified bi-allelic variants in the POPDC2 gene as the cause of a rare inherited cardiac syndrome characterized by sinus node dysfunction, atrioventricular (AV) conduction defects and hypertrophic cardiomyopathy.
Abdominal aortic aneurysm is a life-threatening cardiovascular disease characterized by chronic inflammation and irreversible dilatation of the abdominal aorta and is asymptomatic at the early stages of the disease, with diagnosis usually relying on imaging techniques and surgery being the main approach for treating it.
Myocardial hypertrophy is a condition characterized by thickening of the ventricular wall and commonly associated with progression to heart failure. It develops when the heart is subjected to biomechanical stress or neurohormonal or hemodynamic stimuli.
Akebia Therapeutics Inc. has identified new derivatives of ([1,2,4]triazolo[5,1-a]isoquinoline-5-carbonyl)glycinate acting as prolyl 4-hydroxylase (PHD) inhibitors.
Hypertensive nephropathy is a major complication of hypertension characterized by inflammation and fibrosis in the kidneys. Recent findings have suggested that agrin may play a critical role in some tissue types such as in the heart or skeletal muscle.
RSS
