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BioWorld - Saturday, December 13, 2025
Home » Topics » Disease categories and therapies » Dermatologic

Dermatologic
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Microscope with slide
Dermatologic

First-in-class oral peptide for IL-17 pathway inhibition unveiled

May 14, 2025
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Researchers from Protagonist Therapeutics Inc. reported the preclinical characterization of PN-881, an oral macrocyclic peptide that inhibits the dimeric forms of IL-17 – AA, AF, and FF.
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Dermatologic

Shenzhen Hujia Technology discovers new NO production inhibitors

May 9, 2025
Shenzhen Hujia Technology Co. Ltd. has described retinol derivatives acting as nitric oxide (NO) production inhibitors reported to be useful for the treatment of acne, aging, skin inflammation and skin hyperpigmentation.
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ViroCAP

Viromed signs deals for cold plasma technology devices

May 2, 2025
By Shani Alexander
Viromed Medical AG recently signed a couple of deals to get its devices based on cold plasma technology into the hands of clinicians to treat patients with skin diseases and pneumological infections.
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Arm wrapped with gauze

Abeona’s rare skin disease gene therapy approved by FDA

April 29, 2025
By Lee Landenberger
No Comments
Barely a year after the U.S. FDA shackled Abeona Therapeutics Inc.’s cell-based gene therapy with a complete response letter, the agency has approved it for treating a rare and genetic skin disease. Zevaskyn (prademagene zamikeracel), for treating wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa, will be priced in the U.S. at $3.1 million.
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Antibodies illustration
Inflammatory

Granite Bio emerges from stealth with focus on antibodies for inflammatory, autoimmune and fibrotic conditions

April 25, 2025
Granite Bio AG has emerged from stealth with $100 million in series A and B funding and a focus on developing first-in-class antibodies that target the root causes of a variety of inflammatory, autoimmune and fibrotic conditions.
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Dermatologic

Hepaitech (Beijing) Biopharma Technology discovers new MRGPRX4 antagonists

April 24, 2025
Hepaitech (Beijing) Biopharma Technology Co. Ltd. has described Mas-related G-protein coupled receptor member X4 (MRGPRX4; SNSR5; SNSR6) antagonists reported to be useful for the treatment of anemia, fungal infections, HIV infections, renal disorders, liver diseases, psoriasis, pruritus and urticaria, among others.
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Inflammatory

Aclaris gains IND clearance for bispecific anti-TSLP/IL-4R antibody

April 23, 2025
Aclaris Therapeutics Inc. has gained IND clearance from the FDA for ATI-052, a bispecific anti-thymic stromal lymphopoietin (TSLP)/interleukin-4 receptor (IL-4R) monoclonal antibody being developed to treat certain immuno-inflammatory diseases. A phase Ia/Ib trial, including a proof-of-concept portion in an undisclosed indication, will begin in the current quarter.
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3D illustration of skin layers
Dermatologic

IDOR-1117-2520 shows promise in the treatment of skin autoimmune diseases

April 22, 2025
CC chemokine receptor 6 (CCR6) is a G-protein coupled receptor involved in guiding immune cells through the body and the hallmark receptor for T helper 17 (Th17) cells, and is also expressed in other immune cell populations, such as B cells and innate lymphoid cells, among others.
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Dermatologic

Shanghai Pharmaceuticals describes new CCR4 antagonists

April 16, 2025
Shanghai Pharmaceuticals Holding Co. Ltd. has identified C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, cancer, systemic lupus erythematosus, rheumatoid arthritis and drug-induced rash. 
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Bradley Burnam, CEO, Turn Therapeutics

Spevigo so-so, innovator takes another Turn at IL-36 in eczema

April 11, 2025
By Randy Osborne
With a promising IL-36 inhibitor for atopic dermatitis (AD, or eczema) at the phase II stage, Turn Therapeutics Inc. has gained $75 million in post-public commitments and meanwhile is pursuing a grassroots strategy to keep the coffers in balance.
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