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BioWorld - Tuesday, June 16, 2026
Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Gastrointestinal

New preclinical data on CVI-2742 for treating MASH

Nov. 21, 2024
The efficacy and capabilities of CVI Pharmaceuticals Inc.'s CVI-2742, a THR-β agonist, were tested in nonhuman primates.
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Concept of business partnership

Apollo signs near-$1B deal for Sunshine’s FGF21/GLP-1 injection

Nov. 19, 2024
By Marian (YoonJee) Chu
Apollo Therapeutics Group Ltd. and Sunshine Lake Pharma Co. Ltd. inked a potential $938 million licensing deal for APL-18881 (HEC-88473), Sunshine’s dual fibroblast growth factor 21 (FGF21)/glucagon-like peptide-1 (GLP-1) receptor agonist currently in a phase II study for type 2 diabetes.
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Diagram of how cells take up glucose from the stomach and insulin from the pancreas
Endocrine/metabolic

Astrazeneca exercises option for type 1 diabetes Treg cell therapy program with Quell

Nov. 18, 2024
Astrazeneca plc has selected a candidate to progress under its type 1 diabetes regulatory T cell (Treg) therapy program with Quell Therapeutics Ltd. The company has exercised its exclusive option to license the therapy for further development and commercialization, resulting in a milestone payment to Quell of $10 million.
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Female healthcare professional holding dollar sign
Women's health

Despite women’s health inroads, lackluster funding impedes progress

Nov. 15, 2024
By Karen Carey
While women make up half the world’s population and own two out of every five businesses, there are substantial knowledge gaps about conditions affecting their health – mostly due to decades of research excluding women from clinical trials and investment decisions.
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Female healthcare professional holding dollar sign
Healing the health divide

Despite women’s health inroads, lackluster funding impedes progress

Nov. 14, 2024
By Karen Carey
While women make up half the world’s population and own two out of every five businesses, there are substantial knowledge gaps about conditions affecting their health – mostly due to decades of research excluding women from clinical trials and investment decisions.
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Green strand of DNA

PRV sweetens PTC approval of Kebilidi in AADC deficiency

Nov. 14, 2024
By Randy Osborne
PTC Therapeutics Inc.’s accelerated go-ahead from the U.S. FDA for Kebilidi (eladocagene exuparvovec-tneq), a recombinant adeno-associated virus serotype 2-based gene therapy to treat aromatic L-amino acid decarboxylase (AADC) deficiency, came with a priority review voucher (PRV) that the company intends to monetize.
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Endocrine/metabolic

Islet-targeted gene therapy RJVA-001 leads to durable weight loss in obese mice

Nov. 14, 2024
Researchers from Fractyl Health Inc. presented preclinical data for RJVA-001, a novel pancreatic gene therapy.
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Group of multigenerational, multiracial women

Healing a health divide (that’s long overdue)

Nov. 14, 2024
By Lynn Yoffee
It’s difficult to fathom that the health of half the world’s population is underserved. But it’s a hard truth. There are many conditions that disproportionately impact women. Other conditions and diseases affect women in different ways than men. Decades of research excluding women from clinical trials and investment decisions in male-dominated board rooms have ignored these facts. Though an increasing number of women are now managing investments and driving the research, it’s all still woefully behind. In BioWorld’s new report, Healing the health divide, we’ve highlighted the disparities.
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Amgen stock holds steady as company dismisses analyst report

Nov. 13, 2024
By Lee Landenberger
Amgen Inc. has shrugged off a Cantor Fitzgerald analyst report that wiped about $12 billion from the company’s market cap. The Nov. 12 analyst report noted supplemental data from the company’s phase I study of obesity drug Maritide showing bone mineral density loss in patients.
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Concept of business partnership

Apollo signs near-$1B deal for Sunshine’s FGF21/GLP-1 injection

Nov. 13, 2024
By Marian (YoonJee) Chu
Apollo Therapeutics Group Ltd. and Sunshine Lake Pharma Co. Ltd. inked a potential $938 million licensing deal for APL-18881 (HEC-88473), Sunshine’s dual fibroblast growth factor 21 (FGF21)/glucagon-like peptide-1 (GLP-1) receptor agonist currently in a phase II study for type 2 diabetes.
Read More
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