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BioWorld - Monday, May 4, 2026
Home » Topics » Disease categories and therapies » Neurology/psychiatric

Neurology/psychiatric
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Neurology/Psychiatric

Intra-Cellular Therapies patents 5-HT2A, μ-opioid and dopamine D1/D2 receptor ligands

Oct. 11, 2023
An Intra-Cellular Therapies Inc. patent describes new 5-HT2A, μ-opioid, and dopamine D1 and D2 receptor ligands reported to be useful for the treatment of neurological disorders.
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Parkinson's disease illustration showing neurons containing alpha-synuclein
Neurology/Psychiatric

Stem Pharm and Verge Genomics collaborate on disease model to validate Parkinson’s targets

Oct. 11, 2023
Stem Pharm Inc. and Verge Genomics (Verge Analytics Inc.) have established a collaboration to develop a disease model to validate novel targets identified by Verge for Parkinson’s disease.
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Neurology/Psychiatric

Novel 15-PGDH inhibitor improves muscle force in models of SMA and muscle atrophy

Oct. 11, 2023
It has been previously demonstrated that therapeutic inhibition of the prostaglandin E2 (PGE2)-degrading enzyme, 15-prostaglandin dehydrogenase (15-PGDH), was able to improve muscle strength in aged mice. Researchers from Epirium Bio Inc. have now reported the discovery and preclinical characterization an orally bioavailable small molecule inhibitor of 15-PGDH – MF-300 – being developed for the treatment of neuromuscular dysfunction.
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Neurology/Psychiatric

CaMK2A modulators reported in University of California Oakland and University of Copenhagen patent

Oct. 10, 2023
University of California Oakland and University of Copenhagen scientists have jointly developed calcium/calmodulin-dependent protein kinase type II subunit α (CaMK2A) modulators reported to be useful for the treatment of brain injury, narcolepsy, Angelman syndrome, Down syndrome and stroke.
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Neurology/Psychiatric

Sosei and Pharmenable expand drug discovery collaboration to include second neurology target

Oct. 10, 2023
Sosei Group Corp. and Pharmenable Therapeutics Ltd. have expanded their collaboration to apply their respective technologies to drive novel drug discovery for a second neurological disease target.
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Neurology/Psychiatric

Curasen receives investment to advance α1A-AR agonist for Alzheimer’s disease

Oct. 10, 2023
Curasen Therapeutics Inc. has received a strategic investment of up to $5.8 million from the Alzheimer’s Drug Discovery Foundation (ADDF) to advance CST-3056, an α1A-adrenoceptor (α1A-AR) agonist for the treatment of Alzheimer’s disease.
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Biomarkers

Cathepsin C and PDGFR-α as novel biomarkers of prevalent distal sensorimotor polyneuropathy

Oct. 10, 2023
Researchers from Heinrich-Heine-Universität Düsseldorf and affiliated organizations presented data from a study that aimed to identify novel neurological biomarkers in distal sensorimotor polyneuropathy (DSPN).
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AI generated illustration of a brain on fire
Neurology/Psychiatric

ECNP 2023: Look for antibodies in idiopathic psychoses? First, maybe better tests

Oct. 10, 2023
By Anette Breindl
For individuals who develop an unexpected psychosis, there is something to be said for testing them for autoimmune antibodies. And something against. At the 36th Congress of the European College of Neuropsychopharmacology (ECNP) this week, the topic was worth a controversy session, where speakers presented the pros and cons of the approach. Currently used tests have a specificity of 99%. But as Ester Coutinho, consultant neurologist at the University of Coimbra, pointed out, the validity of diagnostic tests depends on the prevalence of the disorder one is looking for as well. Coutinho estimated that autoimmune psychoses account for 1% of psychoses overall.
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Inbrain graphene-based cortical brain interface

Inbrain granted breakthrough device designation for graphene-based neural platform

Oct. 9, 2023
By Shani Alexander

Inbrain Neuroelectronics SL was granted a breakthrough device designation from the U.S. FDA for its graphene-based neural platform as an adjunctive therapy for treating Parkinson’s disease. The platform, called intelligent network modulation system, harnesses the power of graphene and artificial intelligence to deliver highly focused, adaptive neuroelectronic therapy that re-balances pathological neural networks, easing the symptoms of Parkinson’s.


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Neurology/Psychiatric

Shanghai Institute of Materia Medica patent describes Nav1.8 blockers

Oct. 9, 2023
Amide compounds acting as sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain, arthritis, pruritus, asthma, multiple sclerosis, arrhythmia, heart failure and epilepsy, among others.
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