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BioWorld - Thursday, January 22, 2026
Home » Topics » Disease categories and therapies » Neurology/psychiatric

Neurology/psychiatric
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Neurology/psychiatric

Humanwell discovers new Nav1.8 blockers

Sep. 4, 2025
Humanwell Pharmaceutical US Inc. has described sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain, arrhythmia, cough, urinary incontinence and multiple sclerosis.
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Antibodies illustration
Neurology/psychiatric

FSH-blocking antibody shows potential in obesity, Alzheimer’s models

Sep. 4, 2025
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Researchers from Mount Sinai Center for Translational Medicine and Pharmacology at Icahn School of Medicine at Mount Sinai and colleagues have developed a therapeutic humanized antibody that blocks the action of follicle-stimulating hormone (FSH), a pituitary hormone previously thought to only play a role in fertility.
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Pediatric brain illustration
Neurology/psychiatric

Saniona names SAN-2668 clinical candidate for pediatric epilepsy

Sep. 4, 2025
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Saniona AB has selected SAN-2668 as a first-in-class clinical candidate for pediatric epilepsy.
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Stock table, gold arrow pointing down

Argenica’s stock drops 56% on mixed phase II results

Sep. 3, 2025
By Tamra Sami
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Argenica Therapeutics Ltd. saw its stock drop 56% following mixed results for its ARG-007 phase II Seancon trial in acute ischemic stroke patients undergoing endovascular revascularization, or thrombectomy.
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Illustration of damaged brain, neurons
Cancer

Neuronal damage promotes tumor proliferation and drug resistance

Sep. 3, 2025
By Mar de Miguel
No Comments
Two independent studies have linked neuronal injury, inside or outside the brain, to cancer progression and offer new biomarkers and strategies for prevention. While cerebral cancer cells damage axons and drive tumor development, in other types of cancer affecting other organs, nerve disruption caused by tumor proximity triggers inflammation and a suppressive environment that may also be associated with immunotherapy resistance.
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Neurology/psychiatric

Aglaeapharma discovers new α2-adrenoceptor agonists

Sep. 3, 2025
Aglaeapharma Inc. has described compounds acting as α2-adrenoceptor agonists reported to be useful for the treatment of rhinitis, pain, insomnia, inflammatory disorders, glaucoma, cancer, anesthesia and acute kidney injury, among others.
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Neurology/psychiatric

Aconcagua Bio divulges new calcitonin receptor and amylin receptor agonists

Sep. 3, 2025
Aconcagua Bio Inc. has synthesized calcitonin receptor (CALCR; CT-R) and amylin receptor agonists reported to be useful for the treatment of pain, neurodegeneration, metabolic diseases, bone disease, periodontal disease, metabolic dysfunction-associated steatotic liver disease MASLD), osteogenesis imperfecta and cardiovascular disorders, among others.
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Neurology/psychiatric

Shanghai Shenshi Wise Technology patents new Kv1.3 blockers

Sep. 3, 2025
Shanghai Shenshi Wise Technology Co. Ltd. has disclosed potassium voltage-gated channel subfamily A member 3 (KCNA3; Kv1.3) blockers reported to be useful for the treatment of Alzheimer’s disease, obesity, kidney fibrosis, type 2 diabetes and more.
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Female scientist looking through microscope
Neurology/psychiatric

PARP7 inhibition relieves EAE by modulating type I interferon signaling

Sep. 3, 2025
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The regulation of type I interferon (IFN-1) signaling is crucial for fine-tuning the innate immune response to combat pathogens, fight cancer and prevent autoimmune diseases. Disrupted IFN-1 signaling plays a key role in autoimmune and inflammatory diseases. Therefore, understanding how IFN-1 production and signaling are regulated could reveal new approaches for treating conditions driven by this pathway.


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Demyelination of a neuron
Neurology/psychiatric

Grant supports evaluation of Neucore’s exosome platform for CMT1A

Sep. 3, 2025
No Comments
Neucore Bio Inc. has received a $350,000 STTR phase I grant from the National Center for Advancing Translational Sciences (NCATS) at the U.S. National Institutes of Health (NIH) to evaluate the company’s targeted exosome platform to deliver an RNA-based therapy to treat Charcot-Marie-Tooth disease type 1a (CMT1A).
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