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BioWorld - Wednesday, June 18, 2025
Home » Topics » Disease categories and therapies » Ocular

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Australian coins and bills

PYC’s AU$74M advancing RNA therapy for retinitis pigmentosa

March 19, 2024
By Tamra Sami
PYC Therapeutics raised AU$40 million of an anticipated AU$74 million (US$48.6 million) capital raise to advance three candidates, including lead candidate VP-001, which could potentially be the first treatment for retinitis pigmentosa type 11 (RP11), which causes blindness that begins in childhood and ultimately leads to legal blindness by middle age.
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Australian coins and bills

PYC’s AU$74M advancing RNA therapy for retinitis pigmentosa

March 18, 2024
By Tamra Sami
PYC Therapeutics raised AU$40 million of an anticipated AU$74 million (US$48.6 million) capital raise to advance three candidates, including lead candidate VP-001, which could potentially be the first treatment for retinitis pigmentosa type 11 (RP11), which causes blindness that begins in childhood and ultimately leads to legal blindness by middle age.
Read More

Ocuterra DR:EAM crashes on phase II diabetic retinopathy failure

March 14, 2024
By Karen Carey
Top-line phase II results of privately held Ocuterra Therapeutics Inc.’s novel selective small-molecule RGD integrin inhibitor, nesvategrast (OTT-166), showed it failed to meet primary and key secondary endpoints in patients with diabetic retinopathy, prompting the Boston-based company to seek strategic alternatives.
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Cognition adding $11.5M in public offering for Alzheimer’s drug

March 12, 2024
By Caroline Richards
With early phase II trial data from Cognition Therapeutics Inc.’s lead candidate, CT-1812, for Alzheimer’s disease expected in mid-2024, the firm is hoping to raise $11.5 million from an underwritten public offering of about 6.6 million shares, priced at $1.75 each.
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FDA clears Formosa’s eye drop for postsurgical pain, inflammation

March 5, 2024
By Marian (YoonJee) Chu
Taiwan’s Formosa Pharmaceuticals Inc. and Aimmax Therapeutics, Inc. said the U.S. FDA approved APP-13007 (clobetasol propionate ophthalmic suspension 0.05%), a twice-daily corticosteroid eye drop for postoperative eye pain and inflammation.
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Face with digital focus on eye

Exonate’s topical retinal disease drug to advance on early data

March 5, 2024
By Caroline Richards
Exonate Ltd. is preparing to advance its eye drop candidate to treat retinal vascular diseases, EXN-407, into a phase IIb study following promising tolerability and early signs of efficacy in a phase Ib/IIa study. A small-molecule SRPK1 inhibitor, EXN-407 is designed to be administered twice daily and works by selectively targeting specific (proangiogenic) isoforms of VEGF that lead to vascular retinal disease progression via aberrant growth of leaky blood vessels within the eye.
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Tarsus beefs up blepharitis drug launch on back of $100M offering

March 1, 2024
By Caroline Richards
With its sights set on expanding the commercial launch of Xdemvy (lotilaner ophthalmic solution, 0.25%) to treat Demodex blepharitis in the U.S., Tarsus Pharmaceuticals Inc. has priced an underwritten public offering of common stock, selling 2.8 million shares for $32 each, taking the expected gross proceeds to about $100 million.
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Green strand of DNA

Pulsesight advancing eye therapies delivered via electroporation

Feb. 29, 2024
By Nuala Moran
Ocular gene therapy specialist Pulsesight Therapeutics SAS has launched with seed funding and is raising a series A to take forward two programs using electroporation to deliver plasmid DNA in the treatment of wet age-related macular degeneration and geographic atrophy.
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Green strand of DNA

Pulsesight advancing eye therapies delivered via electroporation

Feb. 28, 2024
By Nuala Moran
Ocular gene therapy specialist Pulsesight Therapeutics SAS has launched with seed funding and is raising a series A to take forward two programs using electroporation to deliver plasmid DNA in the treatment of wet age-related macular degeneration and geographic atrophy.
Read More
Eye and financial charts

Palatin to tweak second PL-9643 phase III in dry eye disease

Feb. 28, 2024
By Randy Osborne
After trading as low as $2.04, shares of Palatin Technologies Inc. (NYSE:PTN) closed Feb. 28 down $1.57, or 39.7%, ending at $2.39 on word of results from the phase III pivotal Melody-1 trial with melanocortin pan-agonist PL-9643 vs. vehicle in dry eye disease.
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