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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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CSPC headquarters

CSPC hints at three upcoming deals worth $5B for EGFR ADC, others

June 3, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. on May 30 disclosed that the company was engaged in ongoing negotiations with unnamed, independent third parties regarding three license deals and collaborations that could total up to $5 billion combined.
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Scientists shaking hands in the lab
Inflammatory

Sanofi exercises option to license STAT6 program from Nurix collaboration

June 3, 2025
No Comments
Sanofi SA has exercised its option to exclusively license Nurix Therapeutics Inc.’s STAT6 program, including the drug development candidate NX-3911, an oral, highly selective STAT6 degrader.
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Lungs
Inflammatory

Recludix nominates oral STAT6 inhibitor as development candidate for inflammatory diseases

June 3, 2025
No Comments
Recludix Pharma Inc. has nominated a lead development candidate, REX-8756, an oral, selective and reversible small-molecule inhibitor of STAT6, and completed GLP toxicology studies for the compound. REX-8756 has potential for patients with type 2 immune-related inflammatory diseases.
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Lungs and bronchi
Respiratory

Quinoline RCD-405 as a potential next-generation bronchodilator

June 2, 2025
No Comments
Bronchodilators are front-line weapons against asthma and chronic obstructive pulmonary disorder. The search continues for next-generation dilators, which so far has largely produced compounds that are no better than existing ones and that often present safety problems.
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AI generated illustration of lungs in the human body
Respiratory

MMP-7 inhibitor exhibits antifibrotic effects in preclinical IPF

June 2, 2025
No Comments
Preclinical findings have shown matrix metalloproteinase 7 (MMP-7) inhibition confers antifibrotic effects and thus, is a promising therapeutic strategy to treat idiopathic pulmonary fibrosis (IPF). Changchun Genescience Pharmaceutical Co. Ltd. has presented data on the siRNA technology-based MMP-7 inhibitor GenSciP117 for treating IPF.
Read More
CSPC headquarters

CSPC hints at three upcoming deals worth $5B for EGFR ADC, others

May 30, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. on May 30 disclosed that the company was engaged in ongoing negotiations with unnamed, independent third parties regarding three license deals and collaborations that could total up to $5 billion combined.
Read More
Lungs wireframe illustration

Split ends itepekimab in COPD? Regeneron phase III setup hairy

May 30, 2025
By Randy Osborne
No Comments
Facing erosion of its mighty Eylea (aflibercept) franchise and near-term loss of exclusivity with Dupixent (dupilumab), Regeneron Pharmaceuticals Inc. took a blow as one of two phase III trials with IL-33-blocking monoclonal antibody itepekimab failed in chronic obstructive pulmonary disease (COPD). The Tarrytown, N.Y.-based firm’s shares (NASDAQ:REGN) closed May 30 at $490.28, down $115.11, or 19%. Partner Sanofi SA, of Paris, saw its stock (NASDAQ:SNY) dip somewhat, too, and ended at $49.37, down $2.98. Cantor analyst Carter Gould opined that the latest news “all but [ruled] out a path forward short of a new study” with the compound.
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AI-generated art for viral infection of the lungs
Infection

Apollo Therapeutics’ APL-10456 exerts strong immune response against rhinovirus

May 28, 2025
No Comments
Rhinovirus (RV) infection is among the most common respiratory infections causing exacerbations of chronic obstructive pulmonary disease and asthma. The high antigenic diversity of RV is a barrier to the development of effective cross-protective vaccines for RV infection.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

Teva begins IND-enabling studies with BD-9

May 28, 2025
No Comments
Teva Pharmaceutical Industries Ltd. has commenced IND-enabling studies with BD-9, a dual-specific multibody targeting thymic stromal lymphopoietin (TSLP) and interleukin-13 (IL-13). By simultaneously blocking two key drivers of TH2-driven inflammation, BD-9 has the potential to improve outcomes for patients with conditions such as atopic dermatitis and asthma.
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Respiratory

An anti-inflammatory α-diazoester to treat acute lung injury

May 27, 2025
No Comments
Activation of the α7 nicotinic acetylcholine receptor may be therapeutically useful against acute lung injury by suppressing expression of pro-inflammatory genes.
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