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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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3D illustration showing surface glycoprotein spikes hemagglutinin (purple) and neuraminidase (orange)
Respiratory

A compound that inhibits cell death prevents severe flu

April 16, 2024
By Mar de Miguel
An enzyme that activates cell death could be targeted to avoid the inflammation and lung lesions caused by influenza A virus (IAV). A collaborative study demonstrated that an inhibitor of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) blocked necroptosis in infected alveolar epithelial cells and prevented the consequences in the lungs of severe disease.
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Scanning electron microscope image of SARS-CoV-2.
Respiratory

Interstitial macrophages trigger severe COVID in the lung

April 12, 2024
By Mar de Miguel
SARS-CoV-2 could proliferate in the lungs causing severe COVID-19 through a special type of immune cell. A group of scientists from Stanford University observed how this coronavirus infected interstitial macrophages through a CD209 receptor, triggering the inflammatory response observed in hospitalized patients.
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SpeeDx Diagnostics

Speedx launches qPCR panel to detect 14 different viruses

April 10, 2024
By Tamra Sami
Australia’s Speedx Pty Ltd. is launching a new rapid polymerase chain reaction (qPCR) test for 14 different respiratory viruses in a single test that works on almost every commercial PCR platform in half the time and at a fraction of the cost of what its competitors charge.
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Hollo Medical haptic feedback flow rate control valve 4-5

Hollo Medical’s product to improve the lives of inhaler users

April 5, 2024
By Simon Kerton
In what represents its first patenting, Halifax, Nova Scotia-based Hollo Medical Inc. seeks protection for its product that is designed for inhaler users who are frustrated with cumbersome valved holding chambers and desire something more compact and portable.
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Paragonix Technologies Inc.’s Baroguard donor lung preservation system

Paragonix breathes easier with Baroguard national launch

April 5, 2024
By Annette Boyle
Paragonix Technologies Inc. expanded access to its U.S. FDA-cleared Baroguard donor lung preservation system following a successful limited release with a handful of top transplant centers. In addition to critical temperature control, the new system provides active airway management to keep donor lungs in the best condition possible.
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Lungs
Respiratory

CHF-6366 and its backup CHF-6550 as inhaled candidates for the treatment of COPD

April 4, 2024
Chiesi Farmaceutici SpA presented data for novel lung-targeted muscarinic M3 receptor antagonists/β2-adrenoceptor agonists (MABAs) as candidates for the treatment of chronic obstructive pulmonary disease (COPD).
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Obesity and heart disease illustration

Coreline Soft wins FDA approval, raises ₩18B in private placement

April 3, 2024
By Marian (YoonJee) Chu
South Korean medical software firm Coreline Soft Co. Ltd. said it gained U.S. FDA 510(k) clearance for its artificial intelligence-based coronary artery calcification assessing solution, Aview CAC, while raising ₩18 billion (US$13.33 million) in a private placement.
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Respiratory

Chiesi Farmaceutici divulges new JAK inhibitors for respiratory disorders

April 3, 2024
Chiesi Farmaceutici SpA has synthesized heterocyclic derivatives acting as Janus kinase (JAK) inhibitors reported to be useful for the treatment of acute lung injury, asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
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CINA ASPECTS

FDA clears Avicenna.AI tools focused on pulmonary embolism, stroke

March 27, 2024
By Shani Alexander
Avicenna.AI SAS received clearance from the U.S. FDA for two of its artificial intelligence (AI)-based solutions, Cina-Ipe and Cina-Aspects, which provide for the detection of pulmonary embolism (PE) and the assessment of stroke severity in CT scans, respectively.
Read More
AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

AI-driven research identifies pulmonary fibrosis target and inhibitor

March 25, 2024
By Mar de Miguel
Deep learning algorithms have enabled the discovery of molecular structures of interest in biomedicine to design treatments against aggressive diseases such as idiopathic pulmonary fibrosis (IPF). Scientists at Insilico Medicine Inc. selected a target for IPF using artificial intelligence (AI), then designed an inhibitor to block it, and tested it in vitro, in vivo, and in clinical trials.
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