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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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CINA ASPECTS

FDA clears Avicenna.AI tools focused on pulmonary embolism, stroke

March 27, 2024
By Shani Alexander
Avicenna.AI SAS received clearance from the U.S. FDA for two of its artificial intelligence (AI)-based solutions, Cina-Ipe and Cina-Aspects, which provide for the detection of pulmonary embolism (PE) and the assessment of stroke severity in CT scans, respectively.
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AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

AI-driven research identifies pulmonary fibrosis target and inhibitor

March 25, 2024
By Mar de Miguel
Deep learning algorithms have enabled the discovery of molecular structures of interest in biomedicine to design treatments against aggressive diseases such as idiopathic pulmonary fibrosis (IPF). Scientists at Insilico Medicine Inc. selected a target for IPF using artificial intelligence (AI), then designed an inhibitor to block it, and tested it in vitro, in vivo, and in clinical trials.
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Abiomed Impella

Abiomed recalls Impella devices citing risk of ventricle perforation

March 22, 2024
By Mark McCarty
The U.S. FDA posted notice of a medical device correction of Abiomed Inc.'s Impella series of left-side blood pumps because of the risk of perforation of the left ventricle during device placement. The FDA noted that it has received 129 reports of serious injury and 49 reports of fatalities associated with these devices, but did not indicate whether device malfunction was the source of these adverse events. Abiomed advises customers that the device should be implanted “with special care” in patients during active cardiopulmonary resuscitation, and to review some updated warnings in the product’s instruction for use statement.
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Lungs wireframe illustration
Respiratory

New agonist of β2-adrenoceptors improves lung function in model of COPD

March 21, 2024
Researchers from Shenyang Pharmaceutical University have discovered novel β2-adrenoceptor (β2-AR) agonists for the treatment of chronic obstructive pulmonary disease (COPD).
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Hutom

Hutom to ‘reshape, unravel surgery’ with AI-surgical navigation

March 20, 2024
By Marian (YoonJee) Chu
Surgeon, CEO and founder of Hutom Corp., Woo Jin Hyung, is working to level the playing field in the operating room with artificial intelligence (AI) and big data, leveraging digital technology to optimize surgical outcomes.
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Vicore digital therapy app

Vicore receives breakthrough device designation for lung disease digital therapy

March 20, 2024
By Shani Alexander
Vicore Pharma Holding AB was granted a U.S. FDA breakthrough device designation for Almee, a cognitive behavioral therapy (CBT) software, to be used as an adjunct treatment by patients with anxiety symptoms due to pulmonary fibrosis. Vicore developed the nine-week CBT digital therapy in partnership with Alex Therapeutics AB.
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Respiratory

New glucocorticoid receptor agonists divulged by Jinyao Biotechnology

March 15, 2024
Jinyao Biotechnology (Tianjin) Co. Ltd. has synthesized glucocorticoid receptor (GR) agonists reported to be useful for the treatment of psoriasis, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, eczema, allergic rhinitis and Crohn’s disease.
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Lungs
Respiratory

China NMPA approves IND for Henlius’ anti-GARP/TGF-β1 mAb for IPF

March 14, 2024
Shanghai Henlius Biotech Inc.’s IND application for HLX-6018, a novel anti-glycoprotein-A repetitions predominant (GARP)/transforming growth factor-β1 (TGF-β1) monoclonal antibody (mAb), has received approval by China’s National Medical Products Administration (NMPA) for the treatment of idiopathic pulmonary fibrosis (IPF).
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Respiratory

Korean researchers develop adenosine A3 receptor agonists for pulmonary fibrosis

March 7, 2024
Korea Institute of Radiological and Medical Sciences, Nextgen Bioscience Co. Ltd. and Yonsei University have jointly prepared purine derivative compounds acting as adenosine A3 receptor agonists reported to be useful for the treatment of pulmonary fibrosis.
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$182M for Sionna’s ‘new standard of care’ in cystic fibrosis

March 6, 2024
By Randy Osborne
Sionna Therapeutics Inc.’s approach with small molecules in cystic fibrosis (CF) yielded the Boston-based firm an upsized and oversubscribed $182 million series C financing. The company is working on drugs that could fully restore the function of the CF transmembrane conductance regulator protein by stabilizing the first nucleotide-binding domain (NBD1). Four compounds are expected to enter the clinic this year – three NBD1 stabilizers and one ICL4 modulator.
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