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Home » Topics » Drugs » Antibody-drug conjugate

Antibody-drug conjugate
Antibody-drug conjugate RSS Feed RSS

Cancer cells being destroyed by immunotherapy
Newco news

Avidicure boosting immune activation with $50M seed round

May 15, 2025
By Nuala Moran
No Comments
Newco Avidicure NV arrived on the scene with a hefty $50 million in seed funding to advance novel antibody formats the company says will surpass the best qualities of first-generation antibodies, checkpoint inhibitors, T-cell engagers and antibody-drug conjugates.
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Lung cancer illustration

US FDA clears Abbvie’s c-Met lung cancer ADC

May 14, 2025
By Karen Carey
No Comments
The U.S. FDA granted Abbvie Inc. accelerated approval for antibody-drug conjugate (ADC) Teliso-V (telisotuzumab vedotin), newly branded Emrelis, making it the first treatment for previously treated advanced non-small-cell lung cancer with high c-Met protein overexpression.
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Qilu nabs China rights to Minghui’s B7-H3 ADC for up to $186M

May 13, 2025
By Tamra Sami
No Comments
Minghui Pharmaceutical Ltd. is out-licensing its antibody-drug conjugate (ADC) MHB-088C to Qilu Pharmaceutical Co. Ltd. for China rights for up to ¥1.345 billion (US$186.44 million). Under terms of the deal, Qilu gains rights to develop and manufacture the ADC in greater China, including mainland China, Hong Kong, Macau, and Taiwan.
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Disitamab vedotin

China’s NMPA gives thumbs up to Remegen’s ADC targeting HER2

May 13, 2025
By Tamra Sami
No Comments
China’s National Medical Products Administration has approved Remegen Co. Ltd.’s antibody-drug conjugate (ADC), disitamab vedotin (RC-48), for treatment of HER2-positive advanced breast cancer in patients with liver metastasis.
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Immuno-oncology

BB-1705 optimizes profile of EGFR-targeting therapies

May 13, 2025
No Comments
Epidermal growth factor receptor (EGFR), when overactive or overexpressed, may lead to tumor growth and spread, and is thus a robust target for therapy.
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Qilu nabs China rights to Minghui’s B7-H3 ADC for up to $186M

May 12, 2025
By Tamra Sami
No Comments
Minghui Pharmaceutical Ltd. is out-licensing its antibody-drug conjugate (ADC) MHB-088C to Qilu Pharmaceutical Co. Ltd. for China rights for up to ¥1.345 billion (US$186.44 million). Under terms of the deal, Qilu gains rights to develop and manufacture the ADC in greater China, including mainland China, Hong Kong, Macau, and Taiwan.
Read More
Immuno-oncology

SYS-6041 shows promise for treating FOLR1-expressing cancers

May 9, 2025
No Comments
Folate receptor α (FOLR1) is highly expressed in the surface of tumoral cells in several cancer types, while it shows limited expression in normal tissues. CSPC Pharmaceutical Group Ltd. has developed a next-generation antibody-drug conjugate (ADC) targeting FOLR1 – SYS-6041 – for the treatment of mid-to-low FOLR1-expressing tumors.
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Immuno-oncology

Anti-CLDN6 QLS-5132 found to have broader therapeutic window

May 9, 2025
No Comments
Claudin-6 (CLDN6) is a protein found in the tight junctions of epithelial cells to modulate their permeability and barrier function, among other actions.
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Immuno-oncology

ADCE-T02 ADC against tissue factor shows strong antitumor activity

May 8, 2025
No Comments
The expression of tissue factor (TF) is limited in normal tissues to the perivascular compartment where it acts as the receptor for the serin protease factor VIIa. This signaling axis triggers the initiation of extrinsic coagulation protease cascade.
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3D illustration of human digestive system
Immuno-oncology

LM-350 shows strong antitumor activity in CDH17-positive models

May 7, 2025
No Comments
Cadherin 17 (CDH17) is a membrane-bound cell adhesion molecule involved in tumor cell proliferation and is selectively overexpressed in several gastrointestinal malignancies, including colorectal cancer, gastric cancer and pancreatic cancer.
Read More
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