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Home » Topics » Drugs » Antibody-drug conjugate

Antibody-drug conjugate
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Hand pointing to IPOs on line graph

Three Korea biotechs prep for May IPOs

May 6, 2025
By Marian (YoonJee) Chu
Among three Korean biotech companies slated to sell shares on the Korea Exchange this month, Immuneoncia Therapeutics Inc. is the latest to price a ₩33.9 billion (US$24 million) Kosdaq IPO for May 19. Regenerative cell therapy maker Organoid Sciences Ltd. and antibody-drug conjugate specialist Intocell Inc. are also gearing up for respective Kosdaq listings starting next week.
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Immuno-oncology

Tyligand develops new dual-action tumor immune agonists for cancer treatment

May 5, 2025
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Tyligand Bioscience Ltd. has reported data on TSN-222, their new cyclic dinucleotide designed as a dual-action tumor immune agonist (DATIA) compound.
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Hand pointing to IPOs on line graph

Three Korea biotechs prep for May IPOs

May 2, 2025
By Marian (YoonJee) Chu
Among three Korean biotech companies slated to sell shares on the Korea Exchange this month, Immuneoncia Therapeutics Inc. is the latest to price a ₩33.9 billion (US$24 million) Kosdaq IPO for May 19. Regenerative cell therapy maker Organoid Sciences Ltd. and antibody-drug conjugate specialist Intocell Inc. are also gearing up for respective Kosdaq listings starting next week.
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3D illustration of tumor
Immuno-oncology

SOT-106: a next-gen LRRC15-directed ADC for sarcoma and aggressive solid tumors

May 2, 2025
No Comments
The leucine-rich repeat-containing protein 15 (LRRC15) is a cell surface protein involved in cell-cell and cell-matrix interactions, with limited expression in normal tissues.
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Immuno-oncology

Obi Pharma gains IND clearance for TROP2-targeting ADC OBI-902

May 2, 2025
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Obi Pharma Inc. has gained IND clearance from the FDA for OBI-902, a TROP2-targeting cancer therapy for advanced solid tumors.
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China in red on globe
Chinabio 2025

US capital crunch pushes China biotechs to roundabout financings

April 29, 2025
By Marian (YoonJee) Chu
Tightening of U.S. regulation and capital is leading Chinese biotechs to alternative and new models of financing, ranging from cross-border licensing deals, M&As, the so-called newco model and overseas listings.
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Handshake with digital globe overlay

Chinabio 2025: Europe-China pharma deals rise as US markets shut

April 29, 2025
By Marian (YoonJee) Chu
Europe was a bigger counterpart to China in pharmaceutical dealmaking than the U.S. last year, speakers at Chinabio Partnering Forum said April 23, and the trend is likely to continue in 2025 with the shuttering of U.S. capital and volatility ailing global markets.
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Orum halts US study of DAC cancer asset after patient death

April 29, 2025
By Marian (YoonJee) Chu
No Comments
Orum Therapeutics Inc. on April 26 pulled the plug on a U.S.-based phase I study of ORM-5029, its lead oncology degrader antibody conjugate (DAC) asset, a decision that came months after the company first reported a patient death in November 2024.
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Immuno-oncology

EO-1022 shows antitumor activity in preclinical solid tumor models

April 29, 2025
HER3 overexpression in solid tumors is tied to poor prognosis, concretely in breast and non-small-cell lung cancers, where treatment resistance often occurs upon using targeted therapy, highlighting the need for novel targeted therapies against HER3. Since its expression is much higher in tumor than normal cells, HER3 is a robust candidate for antibody-drug conjugate (ADC) therapy.
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Immuno-oncology

TROP2-targeting antibody-drug conjugate shows promising results in pancreatic cancer

April 28, 2025
Researchers from Heidelberg Pharma AG have presented a new antibody-drug conjugate (ADC) that shows promise for treating pancreatic ductal adenocarcinoma (PDAC). The ADC, called hRS7 ATAC, targets trophoblast cell surface antigen 2 (TROP2), which is overexpressed in most pancreatic tumors and is associated with aggressive disease and poor prognosis.
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