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Home » Topics » Drugs » Antibody-drug conjugate

Antibody-drug conjugate
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Immuno-oncology

Axcynsis Therapeutics discovers new antibody-drug conjugates

March 20, 2025
Axcynsis Therapeutics Pte Ltd. has described antibody-drug conjugates comprising an antibody or antigen-binding fragment targeting alkaline phosphatase placental type (ALPP) and/or alkaline phosphatase, germ cell type (ALPPL2) covalently linked to a cytotoxic agent through a linker reported to be useful for the treatment of cancer.
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Immuno-oncology

Pinotbio divulges new camptothecin derivatives for cancer

March 20, 2025
Pinotbio Inc. has synthesized camptothecin derivatives and its antibody-drug conjugates reported to be useful for the treatment of cancer.
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Gold dollar sign inside gold cog

Taiho acquiring Araris in $1.14B ADC deal

March 18, 2025
By Nuala Moran
The antibody-drug conjugate (ADC) juggernaut powers on, with Japan’s Taiho Pharmaceutical Co. set to acquire Araris Biotech AG for up to $1.14 billion. Of that, $400 million will be up front, with the remainder tied to milestones with a maximum value of $740 million, around the progress of three ADCs for treating solid and hematological cancers.
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Immuno-oncology

Chinese scientists discover new antibody-drug conjugates

March 18, 2025
Researchers at Concept to Medicine Biotech Co. Ltd., Lepu Biopharma Co. Ltd. and Shanghai Miracogen Inc. have described antibody-drug conjugates consisting of trophoblast glycoprotein (TPBG, 5T4)-targeting antibodies covalently linked to cytotoxic drugs through linkers reported to be useful for the treatment of cancer.
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Rendering of Alteogen’s ALT-B4

Alteogen in $1.35B Medimmune deal; Astrazeneca bids $1B for Esobiotec

March 18, 2025
By Marian (YoonJee) Chu
Alteogen Inc. signed its first billion-dollar partnership this year for ALT-B4 technology through two separate contracts with Astrazeneca plc’s U.K.- and U.S.-based Medimmune subsidiaries worth up to $1.35 billion combined.
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Gold dollar sign inside gold cog

Taiho acquiring Araris in $1.14B ADC deal

March 17, 2025
By Nuala Moran
The antibody-drug conjugate (ADC) juggernaut powers on, with Japan’s Taiho Pharmaceutical Co. set to acquire Araris Biotech AG for up to $1.14 billion. Of that, $400 million will be up front, with the remainder tied to milestones with a maximum value of $740 million, around the progress of three ADCs for treating solid and hematological cancers.
Read More
Rendering of Alteogen’s ALT-B4

Alteogen in $1.35B Medimmune deal; Astrazeneca bids $1B for Esobiotec

March 17, 2025
By Marian (YoonJee) Chu
Alteogen Inc. signed its first billion-dollar partnership this year for ALT-B4 technology through two separate contracts with Astrazeneca plc’s U.K.- and U.S.-based Medimmune subsidiaries worth up to $1.35 billion combined.
Read More
Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Immuno-oncology

Sotio exercises option to license Synaffix technology for ADC programs

March 14, 2025
Sotio Biotech AS is exercising an option under a license and option agreement to obtain a license to Synaffix BV’s technology to develop two bispecific antibody-drug conjugate (ADC) programs  for solid tumors.
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3D rendering of an antibody drug conjugate
Immuno-oncology

Sutro prioritizes preclinical ADC programs

March 14, 2025
Sutro Biopharma Inc. has announced plans to prioritize its three wholly owned preclinical programs in its next-generation antibody-drug conjugate (ADC) pipeline, while deprioritizing additional investment into development of luveltamab tazevibulin across all indications.
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Immuno-oncology

INA-03 demonstrates efficacy in preclinical models of triple-negative breast cancer

March 12, 2025
Inatherys SAS recently presented preclinical data for INA-03, an anti-transferrin receptor (TfR1/CD71) antibody-drug conjugate (ADC), being developed for the treatment of triple-negative breast cancer (TNBC). INA-03 was constructed by conjugating an antimitotic payload (MMAE) to a humanized IgG4 anti-human CD71 antibody using a novel valine-citrulline linker.
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