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Home » Topics » Drugs » Vaccine

Vaccine
Vaccine RSS Feed RSS

More stringency expected under new CBER head

May 6, 2025
By Mari Serebrov
No Comments
U.S. FDA Commissioner Marty Makary is starting to fill the vacancies at the agency that’s seen its senior leadership ravaged by retirements and terminations. Makary’s first pick is Vinay Prasad as the new head of the FDA’s Center for Biologics Evaluation & Research (CBER), the center that oversees vaccines, blood products, allergenics and cellular, tissue and gene therapies.
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Illustration of human papillomavirus particles
Immuno-oncology

Ad-E6/7-HR shows prophylactic and therapeutic preclinical efficacy in HPV-associated cancers

May 5, 2025
No Comments
Human papillomavirus (HPV), particularly the high-risk HPV16 subtype, is a major driver of certain cancers, including cervical, oropharyngeal, anal and penile cancers. The E6 and E7 proteins produced by HPV16 are known to play critical roles in the development of these malignancies, making them attractive targets for therapeutic interventions.
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US HHS touts NIH-developed universal vaccine platform

May 1, 2025
By Mari Serebrov
In a paradigm shift from private-sector partners, the U.S. Department of Health and Human Services (HHS) and the NIH announced May 1 the development of Generation Gold Standard, a next-generation, universal vaccine platform that uses a beta-propiolactone-inactivated, whole-virus to target pandemic-prone viruses.
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Vaccination
Musculoskeletal

New tolerogenic antigen-specific vaccine boosts VISTA+ Tregs and prevents arthritis in RA model

April 29, 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by joint inflammation, cartilage loss and bone damage. Although biological disease-modifying antirheumatic drugs have improved treatment outcomes, the disease remains incurable.
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Hematologic

Vaccination approach prevents clotting without increased bleeding

April 28, 2025
A recent study by researchers from Texas A&M University presented a new vaccine designed to target the ligand-binding domain of the serotonin 2A receptor (5-HT2AR), which resides in the second extracellular loop (EL2) and was previously identified as the key region for receptor activation. The new candidate, called EL2-5HTVac, was shown to provide a long-lasting and selective therapeutic approach to avoid increased bleeding risk complications.
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Drug vials and syringe

Vaccine Integrity Project launched to tackle ‘unfortunate reality’

April 25, 2025
By Nuala Moran
Nervousness about the Trump administration’s attitude to vaccines has spurred the formation of the Vaccine Integrity Project, which has the aim of safeguarding the use of vaccines and ensuring vaccine policy “remains grounded in the best available science,” and is “free from external influence.”
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Influenza A virus (H3N2)
Immune

Poly-epitope influenza vaccine candidate triggers T-cell immunity across strains

April 23, 2025
Writing in Scientific Reports, researchers from the Stiftung Tieraerztliche Hochschule Hannover and collaborators present the design and evaluation of an artificial poly-epitope sequence comprising 20 potentially immunogenic conserved influenza A virus CD8+ T cell epitopes as a new vaccine candidate.
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Immune

Nanobody against mpox virus: from screening to crystal structure

April 23, 2025
Researchers at the Chinese Academy of Medical Sciences and Peking Union Medical College have prepared a nanobody against mpox virus.
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Illustration of neurons with Lewy bodies
Neurology/psychiatric

Parkinson’s vaccine selectively targets pathogenic αSyn

April 17, 2025
At the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD), Promis Neurosciences Inc. presented its new approach to optimizing the α-synuclein (α-Syn) vaccine composition in order to maximize targeting of toxic α-Syn species.
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Neurology/psychiatric

Alzheimer’s vaccine selectively targets toxic amyloid-β oligomers

April 17, 2025
Promis Neurosciences Inc. recently presented the rational design of an Alzheimer’s disease (AD) vaccine candidate maximizing the selective targeting of toxic amyloid-β oligomers.
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