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Home » Topics » Infection » Coronavirus

Coronavirus
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In the clinic for Oct. 1, 2024

Oct. 1, 2024
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Alnylam, Anagram, Angitia, Ascendis, BMS, Bridgebio, Cereno, Cour, CSL, Enliven, Estrella, Janssen, Kezar, Madrigal, Neurobo, Ocuphire, Pop, Poseida, Rivus, Windtree.
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Infection

Tohoku University patents new 3CLpro inhibitors

Oct. 1, 2024
Tohoku University has disclosed 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections and inflammatory disorders.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Discovery of macrocyclic 3CLpro inhibitors with improved PK properties

Sep. 30, 2024
In work at Shanghai Curegene Pharmaceutical Co. Ltd., synthesis and optimization of a series of SARS-CoV-2 3CL protease (3CLpro, Mpro) inhibitors led to the identification of compounds [I], [II] and [III] as lead candidates suitable for further evaluation, based on their enzymatic IC50s (14, 12 and 8.6 nM, respectively), cellular EC50s (36, 26 and 52 nM, respectively) and human liver microsome (HLM) stability.
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Regulatory actions for Sept. 23, 2024

Sep. 23, 2024
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Amplia, Apellis, Biocon, Biotech, Ipsen, Janssen, Johnson & Johnson, Merck, Novo Nordisk, Pfizer, Samsung Bioepis, Sanofi.
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Infection

Discovery and characterization of second-generation oral Mpro inhibitors

Sep. 20, 2024
Details on the work leading to the discovery of the second-generation SARS-CoV-2 main protease (Mpro) inhibitor PF-7817883 (ibuzatrelvir) were disclosed recently by Pfizer Inc. The drug is in phase II clinical development for the treatment of adult individuals with COVID-19 symptoms who are not hospitalized.
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Regulatory actions for Sept. 19, 2024

Sep. 19, 2024
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Accord, Applied, Astrazeneca, Azitra, Briacell, Glycomine, Imcheck, Merck, Moderna, Nicox, Novartis, Valneva.
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Infection

Insilico Medicine divulges new Mpro inhibitors for SARS-CoV-2

Sep. 19, 2024
Insilico Medicine Inc. has synthesized 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Infection

Rutgers University divulges new PL-pro inhibitors

Sep. 18, 2024
The State University of New Jersey (Rutgers) has synthesized non-structural protein 3 (nsp3; PL-pro) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections.
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In the clinic for Sept. 16, 2024

Sep. 16, 2024
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Atea, Curevac, Hotspot Therapeutics, Immuneering, Moberg, Neurocrine, Vico, Zambon.
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Moderna signage

Moderna falls on R&D cuts, filing delays, terminated programs

Sep. 12, 2024
By Karen Carey
Moderna Inc.’s shares (NASDAQ:MRNA) sank 19% to a $64.11 low in early trading Sept. 12 as investors learned during the annual R&D Day event of a $1.1 billion reduction to R&D and the U.S. FDA’s reluctance to support an accelerated approval filing for its individualized neoantigen therapy for melanoma.
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