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BioWorld - Sunday, June 22, 2025
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Home » Topics » BioWorld Science, Cardiovascular

BioWorld Science, Cardiovascular
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Cholesterol plaque in artery
Cardiovascular

PPRHs lower levels of PCSK9 and cholesterol in transgenic mouse without causing toxicity

June 19, 2025
No Comments
Researchers from the Universitat de Barcelona and Oregon Health & Science University have developed a novel gene silencing technique using polypurine reverse Hoogsteen hairpins (PPRH) to target and inhibit the expression of PCSK9.
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3d rendering of bispecific antibodies
Cardiovascular

Diagonal Therapeutics’ DIAG-723 designated orphan drug for hereditary hemorrhagic telangiectasia

June 19, 2025
No Comments
Diagonal Therapeutics Inc.’s DIAG-723 has been awarded orphan drug designation by the FDA for the treatment of hereditary hemorrhagic telangiectasia (HHT). Additionally, the EMA has provided a positive opinion for orphan drug designation, confirming that DIAG-723 meets the criteria for designation as an orphan drug in the E.U.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
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Cardiovascular

Shanghai Qilu Pharmaceutical describes new apolipoprotein A inhibitors

June 13, 2025
Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has divulged compounds acting as apolipoprotein A (ApoA; LPA) inhibitors reported to be useful for the treatment of hyperlipidemia, coronary heart disease, ischemic stroke and myocardial infarction.
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Digital cardiology illustration
Cancer

ICG-001 protects heart from doxorubicin-induced cardiotoxicity

June 13, 2025
No Comments
Doxorubucin is an effective therapeutic in cancer treatment, but it can cause cardiotoxicity and damage the mitochondrial machinery. A new patient-derived and mitochondria-rich human induced pluripotent stem cell derived-cardiomyocyte (hiPSC-CM) model protected by dexrazoxane was developed.
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Molecular research art concept
Inflammatory

Monte Rosa’s molecular glue degrader MRT-8102 gains IND clearance for inflammatory conditions

June 11, 2025
No Comments
Monte Rosa Therapeutics Inc. has gained IND clearance from the FDA for MRT-8102, a NEK7-directed molecular glue degrader being developed to treat inflammatory conditions linked to NLRP3, IL-1β and IL-6 dysregulation.
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Female hands holding heart on cardiogram
Cardiovascular

Nuevocor’s NVC-001 cleared to enter clinic for dilated cardiomyopathy

June 10, 2025
No Comments
Nuevocor Pte. Ltd. has obtained IND clearance by the FDA for NVC-001, an AAV-based gene therapy.
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Cardiovascular

Rednvia patents new TNAP inhibitors for ectopic calcification

June 3, 2025
Rednvia Co. Ltd. has disclosed alkaline phosphatase tissue-nonspecific isozyme (TNAP) inhibitors reported to be useful for the treatment of ectopic calcification.
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Colorful illustration of the heart
Cardiovascular

Circode Biomed’s HM-2002 gains US IND clearance for ischemic heart disease

June 2, 2025
No Comments
Shanghai Circode Biomed Co. Ltd. has obtained IND clearance from the FDA for HM-2002 for ischemic heart disease. It previously received IND clearance in China in January this year.
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Artery and plaque
Cardiovascular

Rona Therapeutics reports preclinical findings with RNAi therapy for cardiovascular disease

May 30, 2025
No Comments
Rona Therapeutics Co. Ltd. has reported preclinical data for its RNA interference (RNAi) therapy RN-026 targeting lipoprotein(a) (Lp[a]).
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