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BioWorld - Monday, August 3, 2026
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Home » Topics » BioWorld Science, Cardiovascular

BioWorld Science, Cardiovascular
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Female doctor and patient

BioFuture 2024: Half the population’s health needs are underserved

Nov. 5, 2024
By Lee Landenberger
While the size of the market is enormous, drug development and treatments for women’s health care still lag behind what is offered for men. There has been a renaissance in the past few years, however, led by investors and companies that have wrestled with determining exactly what encompasses women’s health and how to meet its challenges.
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Cardiovascular

MPO inhibition yields protective efficacy in MPO-ANCA autoimmune vasculitis model

Nov. 5, 2024
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by the inflammation of blood vessels, and it has been demonstrated that myeloperoxidase (MPO) is one of the major disease drivers of AAV, as it is a neutrophil surface protein that binds to ANCA.
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Cardiovascular

AAV-driven gene therapy shows promise for PLN-R14del cardiomyopathy

Nov. 4, 2024
The PLN-R14del mutation is often tied to dilated or arrhythmogenic cardiomyopathy, which can progress to end-stage heart failure. Cardiac phospholamban (PLN) plays a crucial role in calcium modulation in cardiomyocytes, which is disrupted by the PLN-R14del mutation.
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Neutrophil and red blood cells
Endocrine/metabolic

GDF-15 is therapeutic target in type 2 diabetes sequelae

Oct. 31, 2024
Previous studies have shown that NETosis, a specialized form of neutrophil-specific cell death, is involved in the pathogenesis of diabetes.
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3D illustration of heart cross section
Cardiovascular

Bayer exercises option for Dewpoint’s dilated cardiomyopathy program

Oct. 25, 2024
Bayer AG has entered into an exclusive licensing agreement with Dewpoint Therapeutics Inc. for a heart disease program to treat dilated cardiomyopathy (DCM) patients characterized by specific mutations.
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Cardiovascular

Micot (Suzhou) Technology patents new xanthine derivatives for hypertension and asthma

Oct. 24, 2024
Micot (Suzhou) Technology Co. Ltd. has disclosed xanthine derivatives reported to be useful for the treatment of hypertension and asthma.
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Heart scientific overlay
Cardiovascular

Optimized MYBPC3 construct using novel cardiotropic capsid for the treatment of MYBPC3-associated HCM

Oct. 24, 2024
Researchers from Affinia Therapeutics Inc. have described the development and preclinical evaluation of a new AAV-based gene therapy, designed using a novel cardiotropic capsid, for the potential treatment of MYBPC3-associated hypertrophic cardiomyopathy (HCM).
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Time perception clocks
Genetic/congenital

Angiopoietin-2 slows down vascular accelerated aging in progeria

Oct. 23, 2024
By Coia Dulsat
Researchers from the University of Maryland in collaboration with the National Institutes of Health (NIH) and Duke University have identified angiopoietin-2 (Ang2) as a targetable protein to reverse cardiovascular dysfunction in Hutchinson-Gilford progeria syndrome (HGPS).
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Colorful illustration of the heart
Cardiovascular

METTL1 silencing ameliorates cardiac ischemia/reperfusion injury in mice

Oct. 22, 2024
Increasing evidence exists regarding the involvement of methyltransferase 1, tRNA methylguanosine (METTL1) in cardiac repair and fibrosis. The search for new therapeutic targets for alleviating ischemic heart disease due to cardiac ischemia/reperfusion injury (IRI) is of vital importance.
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Illustration of glucose molecules in a bloodstream
Cardiovascular

miR-210 behind diabetes-induced endothelial dysfunction

Oct. 21, 2024
Cardiovascular disease is among the leading causes of death in individuals with type 2 diabetes. The role that microRNA 210 (miR-210) plays in endothelial cells and in diabetes-driven endothelial dysfunction is not clearly understood. Its potential as a therapeutic target was investigated.
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