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BioWorld - Friday, December 12, 2025
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Home » Topics » BioWorld Science, Endocrine/metabolic

BioWorld Science, Endocrine/metabolic
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Endocrine/metabolic

NT-0796 ameliorates MASH phenotype in mice

Nov. 12, 2025
No Comments
There is evidence that NACHT, LRR and PYD domains-containing protein 3 (NLRP3)-driven mechanisms may drive both peripheral and hypothalamic inflammation in preclinical obesity. NLRP3 inflammasome activation has been tied to the pathogenesis of obesity-related metabolic syndrome and its progression.
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Endocrine/metabolic

Eli Lilly divulges new GCGR agonists

Nov. 11, 2025
Eli Lilly and Co. has synthesized glucagon receptor (GCGR) agonists reported to be useful for the treatment of type 2 diabetes and obesity.
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Art concept for metabolism
Endocrine/metabolic

Mwyngil Therapeutics in-licenses GPR75 modulators

Nov. 7, 2025
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Mwyngil Therapeutics Inc. has in-licensed several lead GPR75 modulator molecules and a proprietary cell-surface discovery platform from Expert Systems Inc.
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Endocrine/metabolic

Ascletis Pharma selects new clinical development candidate

Oct. 30, 2025
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Ascletis Pharma Inc. has selected ASC-36, a once-monthly, potentially best-in-class subcutaneously administered amylin receptor peptide agonist, as a clinical development candidate.
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Endocrine/metabolic

Genescience discovers new SLC6A19 inhibitors for PKU

Oct. 29, 2025
Genescience Pharmaceuticals Co. Ltd. has identified sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) inhibitors reported to be useful for the treatment of phenylketonuria (PKU).
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Endocrine/metabolic

Suzhou Spring-Sea Bio-Pharmaceuticals discovers new GLP-1R, GCGR and GIPR agonists

Oct. 27, 2025
Suzhou Spring-Sea Bio-Pharmaceuticals Co. Ltd. has described polypeptides acting as glucagon-like peptide 1 receptor (GLP-1R), glucagon receptor (GCGR) and gastric inhibitory polypeptide receptor (GIPR) agonists reported to be useful for the treatment of dyslipidemia, hepatic steatosis, metabolic syndrome, obesity and type 2 diabetes.
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Lab mouse
Endocrine/metabolic

Neumora’s NMRA-215 demonstrates weight loss in mice

Oct. 27, 2025
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Neumora Therapeutics Inc. has reported preclinical data for NMRA-215, a brain-penetrant, oral NLRP3 inhibitor in development for obesity, suggesting potential utility as a monotherapy as well as in combination with a GLP-1 agonist.
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Tape measure, apple on scale
Endocrine/metabolic

Triple-receptor agonists for treating obesity and type 2 diabetes

Oct. 24, 2025
No Comments
Activating the glucagon-like peptide 1 receptor (GLP-1R) is the mechanism of action of most drugs currently used to treat obesity and type 2 diabetes. To enhance efficacy and reduce side effects, many groups have been developing double or triple agonists that, at the same time, also stimulate the receptors for glucagon (GCG) or glucose-dependent insulinotropic peptide (GIP).
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Endocrine/metabolic

Preclinical data on single-dose gene editing system for AATD

Oct. 21, 2025
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Alpha-1 antitrypsin deficiency (AATD) is a monogenic disease caused by mutations in the SERPINA1 gene, which encodes alpha-1 antitrypsin (AAT), a serine protease inhibitor mainly produced by hepatocytes.
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Endocrine/metabolic

Genescience Pharmaceuticals describes new PAH stabilizers for PKU

Oct. 17, 2025
Genescience Pharmaceuticals Co. Ltd. has identified phenylalanine hydroxylase (PAH) (R408W mutant) stabilizers reported to be useful for the treatment of phenylketonuria (PKU).
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