JCR Pharmaceuticals Co. Ltd. has received approval from Germany’s Paul-Ehrlich Institute (PEI) for its clinical trial application (CTA) for JR-441, a blood-brain barrier penetrating form of heparan N-sulfatase developed using JCR’s proprietary J-Brain Cargo technology.
Researchers from the Institute of Translational Genomics at Helmholtz Munich have described a genetic overlap between type 2 diabetes (T2D), a disease that is also associated with obesity, and osteoarthritis, a degeneration of the joints that worsens with age and coincides in the factor risk of being overweight. The researchers used genetic data, multiomics and functional analysis of the tissues T2D and osteoarthritis express to identify which genes were associated and correlated with both diseases. They published their results on July 10, 2023, in The American Journal of Human Genetics.
A Pfizer Inc. patent describes new melanocortin MC4 receptor antagonists reported to be useful for the treatment of cachexia, anorexia and anorexia nervosa.
Shionogi & Co. Ltd. has reported aromatic heterocyclic compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists and reported to be useful for the treatment of obesity and type 2 diabetes.
Researchers from Enterin Inc. and affiliated organizations presented preclinical data for ENT-03, an endogenous spermine bile acid with PTP1B inhibitory activity, being developed as a therapy to normalize glycemia and reverse obesity.
Congenital hyperinsulinism is an inherited condition affecting the pancreatic β cells, leading to overproduction of insulin and persistent low blood sugar levels. The most severe type of hyperinsulinism arises from mutations in ABCC8 or KCNJ11 genes, encoding the subunits of two ATP-sensitive potassium channels found in β cells. Diazoxide is the only FDA-approved treatment for hyperinsulinism, but patients with these mutations are unresponsive to this drug and need a pancreatectomy. Therefore, novel therapies for severe hyperinsulinism are urgently needed.
CSPC Pharmaceutical Group Ltd. has announced clinical trial approval by China’s National Medical Products Administration (NMPA) for the antibody drug JMT-203, being developed by the company’s Shanghai JMT-Bio Technology Co. Ltd. subsidiary for cancer cachexia.
Glucagon-like peptide-1 (GLP-1) is a hormone that both acts as a satiety signal in response to food intake and also stimulates insulin release and inhibits glucagon secretion in response to food ingestion. Researchers at Terns Pharmaceuticals Inc. have presented preclinical data on TERN-601, a GLP-1 receptor (GLP-1R) agonist, in humanized GLP-1R (hGLP-1R) mouse models.
Dong-A ST Co. Ltd.’s DA-1726 is a novel oxyntomodulin analogue and balanced glucagon-like peptide-1 receptor (GLP-1R)/glucagon receptor (GCGR) dual agonist under investigation for the treatment of obesity.
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