Celros Biotech Co. Ltd. has identified hydantoin derivatives acting as cytochrome b-245 heavy chain (CYBB; NOX2) and NADPH oxidase 4 (NOX4) inhibitors with blood-brain barrier permeability and metabolic stability reported to be useful for the treatment of atherosclerosis, Alzheimer’s disease, cirrhosis, diabetes, cancer, glomerulonephritis, psoriasis and rheumatoid arthritis, among others.

Inversago Pharma Inc. has synthesized cannabinoid CB1 receptor antagonists reported to be useful for the treatment of cancer, diabetes, fibrosis, hypertension, irritable bowel syndrome, metabolic syndrome, alopecia and Prader-Willi syndrome.

PTC Therapeutics Inc. has patented new NLRP3 inflammasome inhibitors reported to be useful...

Beam Therapeutics Inc. has released new preclinical data demonstrating the ability of its in vivo drug candidate, BEAM-302, to directly correct the PiZ mutation, the primary disease-causing mutation associated with severe α1-antitrypsin deficiency (AATD).

Novartis AG has synthesized glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 2 diabetes, obesity, hypertension, stroke, hyperglycemia, dyslipidemia, nonalcoholic steatohepatitis and diabetic nephropathy, among others.

The Broad Institute of MIT and Harvard has announced a new research alliance with Novo Nordisk A/S in diabetes and cardiometabolic diseases. The collaboration will focus on advancing three programs over the next 3 years.