Codagenix Inc. announced that the U.S. Department of Defense (DoD), through the U.S. Army Medical Research and Development Command and the U.S. Army Medical Research Acquisition Activity, has awarded the company $5.88 million to advance the development of its Codavax-Denv, a tetravalent live attenuated dengue vaccine program.

Appili Therapeutics Inc. has secured a commitment for the second stage of funding for ATI-1701 from the U.S. Air Force Academy (USAFA), who is working in partnership with the Defense Threat Reduction Agency, the funding agency.

Borrelia burgdorferi, one of the bacteria species causing Lyme disease, has a small genome and is therefore highly dependent on its hosts to obtain many necessary metabolites. Its small genome makes B. burgdorferi an attractive candidate for developing narrow-spectrum antibiotics targeting those essential genes. The use of narrow-spectrum antibiotics may reduce the risk of side effects and the spread of antimicrobial resistances compared with traditional, long-term antibiotic treatments.

Researchers from Eradivir Inc. and affiliated organizations presented the discovery and preclinical evaluation of EV-21, a dual mechanism antiviral immunotherapy for the treatment of influenza infections. EV-21 was designed as a ligand-targeted drug conjugate, developed by linking the neuraminidase inhibitor zanamivir to two distinct haptens that bind to two different naturally occurring antibodies in humans. As a result, the candidate acts though a dual mechanism of action, which consists of potent recruitment of the human immune system to recognize and destroy free viruses and virus-infected cells.

Qnovia Inc. has entered into a drug development collaboration with the University of Virginia (UVA) to advance novel inhaled drug candidates.

Gilead Sciences Inc. and Assembly Biosciences Inc. have entered into a 12-year partnership to advance the research and development of novel antiviral therapies, with an initial focus on Assembly’s established areas of herpesviruses, hepatitis B virus (HBV) and hepatitis D virus (HDV).

Researchers from Generate Biomedicines Inc. have detailed the discovery and preclinical characterization of GB-0669, a spike S2-targeted monoclonal antibody (MAb) being developed for the prophylaxis of SARS-CoV-2 infection. Machine learning models were used to identify MAbs targeting the conserved S2 stem helix and RBD class IV region of spike.

At the IDWeek 2023 infectious disease conference held last week in Boston, fungal infections got the audience’s attention during the session titled, “The antifungal evolution: novel strategies for a changing world.” With the emergence of some resistant pathogens such Candida auris and the growing disease burden in the population at risk for life-threatening fungal infections, these pathogens are more than ever standing out within the infectious diseases arena.