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BioWorld - Sunday, May 17, 2026
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Home » Topics » BioWorld Science, Neurology/psychiatric

BioWorld Science, Neurology/psychiatric
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Neurology/Psychiatric

CVN-766 improves negative and cognitive symptoms of schizophrenia in preclinical models

Oct. 13, 2023
At the ECNP meeting this week in Barcelona, researchers from Cerevance Inc. presented preclinical data for the selective orexin OX1 receptor (OX1R) antagonist CVN-766, following evaluation in models of schizophrenia. The potency and selectivity of CVN-766 were assessed in recombinant cells overexpressing either human or mouse OXR1 or OXR2.
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Neurology/Psychiatric

CAMKK2 activators described in Tohoku University patent

Oct. 11, 2023
Work at Tohoku University has led to the identification of new calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2; CAMKKβ) activators.
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Neurology/Psychiatric

Intra-Cellular Therapies patents 5-HT2A, μ-opioid and dopamine D1/D2 receptor ligands

Oct. 11, 2023
An Intra-Cellular Therapies Inc. patent describes new 5-HT2A, μ-opioid, and dopamine D1 and D2 receptor ligands reported to be useful for the treatment of neurological disorders.
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Parkinson's disease illustration showing neurons containing alpha-synuclein
Neurology/Psychiatric

Stem Pharm and Verge Genomics collaborate on disease model to validate Parkinson’s targets

Oct. 11, 2023
Stem Pharm Inc. and Verge Genomics (Verge Analytics Inc.) have established a collaboration to develop a disease model to validate novel targets identified by Verge for Parkinson’s disease.
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Neurology/Psychiatric

Novel 15-PGDH inhibitor improves muscle force in models of SMA and muscle atrophy

Oct. 11, 2023
It has been previously demonstrated that therapeutic inhibition of the prostaglandin E2 (PGE2)-degrading enzyme, 15-prostaglandin dehydrogenase (15-PGDH), was able to improve muscle strength in aged mice. Researchers from Epirium Bio Inc. have now reported the discovery and preclinical characterization an orally bioavailable small molecule inhibitor of 15-PGDH – MF-300 – being developed for the treatment of neuromuscular dysfunction.
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Neurology/Psychiatric

CaMK2A modulators reported in University of California Oakland and University of Copenhagen patent

Oct. 10, 2023
University of California Oakland and University of Copenhagen scientists have jointly developed calcium/calmodulin-dependent protein kinase type II subunit α (CaMK2A) modulators reported to be useful for the treatment of brain injury, narcolepsy, Angelman syndrome, Down syndrome and stroke.
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Neurology/Psychiatric

Sosei and Pharmenable expand drug discovery collaboration to include second neurology target

Oct. 10, 2023
Sosei Group Corp. and Pharmenable Therapeutics Ltd. have expanded their collaboration to apply their respective technologies to drive novel drug discovery for a second neurological disease target.
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Neurology/Psychiatric

Curasen receives investment to advance α1A-AR agonist for Alzheimer’s disease

Oct. 10, 2023
Curasen Therapeutics Inc. has received a strategic investment of up to $5.8 million from the Alzheimer’s Drug Discovery Foundation (ADDF) to advance CST-3056, an α1A-adrenoceptor (α1A-AR) agonist for the treatment of Alzheimer’s disease.
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Biomarkers

Cathepsin C and PDGFR-α as novel biomarkers of prevalent distal sensorimotor polyneuropathy

Oct. 10, 2023
Researchers from Heinrich-Heine-Universität Düsseldorf and affiliated organizations presented data from a study that aimed to identify novel neurological biomarkers in distal sensorimotor polyneuropathy (DSPN).
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AI generated illustration of a brain on fire
Neurology/Psychiatric

ECNP 2023: Look for antibodies in idiopathic psychoses? First, maybe better tests

Oct. 10, 2023
By Anette Breindl
For individuals who develop an unexpected psychosis, there is something to be said for testing them for autoimmune antibodies. And something against. At the 36th Congress of the European College of Neuropsychopharmacology (ECNP) this week, the topic was worth a controversy session, where speakers presented the pros and cons of the approach. Currently used tests have a specificity of 99%. But as Ester Coutinho, consultant neurologist at the University of Coimbra, pointed out, the validity of diagnostic tests depends on the prevalence of the disorder one is looking for as well. Coutinho estimated that autoimmune psychoses account for 1% of psychoses overall.
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