Researchers from Alpha Cancer Technologies Inc. and affiliated organizations presented data from a study that aimed to assess the effects of ACT-101-maytansinoid conjugates in models of colorectal cancer.
Cyclin-dependent kinases (CDK) are serine/threonine kinases that act as regulatory enzymes involved in cell proliferation. The dysregulation of CDK activity occurs through overexpression of cyclin E1, a binding partner of CDK2, which is observed in several cancers such as high-grade serous ovarian cancer (HGSOC), bladder cancer, gastric cancer and estrogen receptor-positive breast cancer, among others. Selective inhibition of CDK2 may thus be considered a therapeutic approach to regaining cell cycle control.
Research led by the University of Copenhagen and Herlev-Gentofte University Hospital shows that individuals with the eating disorder anorexia nervosa have an abnormal gut microbiome that likely contributes to symptoms associated with the condition. Published in the April 17, 2023, issue of Nature Microbiology, the study showed multiple differences in the species and amounts of bacteria and viruses present in the gut of people with the condition compared with healthy controls.
Differences in the immune reactions between smokers and nonsmokers may explain why only 20% of patients with lung cancer respond to immunotherapy treatment. Understanding these differences in the evolution of lung cancer between smokers and nonsmokers could be the key to unlocking new treatments.
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