A new study has uncovered a potential link between RNA regulation and the development of neurodegenerative diseases, such as Parkinson’s disease and dementia. This work, conducted by researchers at the University of Nottingham, used a combination of microscopy and machine learning techniques to examine the role of N6-methyladenosine modification of RNA (m6A) in the human brain.
Adlai Nortye Pharmaceutical Co. Ltd. has described molecular glue degraders acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degraders reported to be useful for the treatment of cancer, viral infections, autoimmune disease and inflammatory disorders.
3+2 Pharma LLC has divulged pyrazole-containing CREB-binding protein (CREBBP; CBP)/β-catenin (CTNNB1) interaction inhibitors reported to be useful for the treatment of fibrosis, cancer, aging, neurological, metabolic and dermatological disorders.
Genentech Inc. has identified sodium channel protein type 9 subunit α (Nav1.7) channel blockers reported to be useful for the treatment of pain, depression, pruritus, cardiovascular, respiratory and psychiatric disorders.
Janssen Biotech Inc. and Yuhan Corp. have synthesized substituted aminopyridine compounds acting as EGFR (HER1; erbB1) (mutant) inhibitors reported to be useful for the treatment of cancer and immunological disorders.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disrupted tolerance against nucleic acids, which form immune complexes with antibodies, finally leading to tissue damage. However, the mechanisms underlying the release of DNA from cells remain unexplained.
Shwachman-Diamond syndrome (SDS) is a rare disease of ribosome biogenesis affecting multiple systems, with predominant manifestations being exocrine pancreatic insufficiency, bone marrow failure and leukemia predisposition, among others.
Researchers from the First Affiliated Hospital of Guangxi Medical University presented data from a study that aimed to assess the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.
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