Research at Medshine Discovery Inc. has led to the development of imidazocyclic compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists potentially useful for the treatment of diabetes.
The expression of zinc finger transcription factor Trps1 (TRPS1) has been recently found to be specific for tumors of the breast. In normal skin, the expression of TRPS1 is found in outer root sheath, sebocytes and matrical cells of the hair follicle, as well as the inner luminal cells of eccrine glands. Cutaneous tumors with origin in these cell types were hypothesized to express TRPS1. Because little knowledge exists about the expression of TRPS1 in nonmelanocytic tumors of the skin; researchers from The University of Texas MD Anderson Cancer Center performed immunohistochemical (IHC) analysis of TRPS1 in different types of cutaneous tumors.
Osteoarthritis and its associated cartilage pathology affects 30 million people in the U.S., but no disease-modifying treatments have yet reached the clinic. A recent multicenter trial evaluating the safety and efficacy of a truncated, recombinant human fibroblast growth factor-18 (FGF18) protein analogue (rhFGF18) demonstrated a dose-dependent improvement in cartilage thickness relative to a placebo.
Nucleoside or nucleotide antivirals are a common first-line treatment for viral diseases, acting as direct inhibitors of viral replication and transcription. The nucleoside GS-441524 and its prodrug remdesivir have shown broad-spectrum antiviral activity against several virus families, including Flaviviridae, Filoviridae, Pneumoviridae, paramyxoviruses and Coronaviridae.
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