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BioWorld - Sunday, May 17, 2026
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Immuno-oncology

Lift Biosciences announces development and manufacturing partnership for N-Lift

Feb. 17, 2023
Lift Biosciences Ltd. and Minaris Regenerative Medicine GmbH have entered into a development and manufacturing partnership for N-Lift, Lift's first-in-class neutrophil progenitor-based leukocyte infusion therapy for the treatment of various cancer indications, including pancreatic cancer, lung cancer and other solid tumors.
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Induced pluripotent stem cells
Ear, Nose & Throat

New patient-derived iPSC line and humanized mouse model of TMEM43-associated hearing loss

Feb. 17, 2023
The TMEM43 gene encodes a transmembrane protein that is associated with connexin-linked function in cochlear glia-like supporting cells (GLSs), and mutations in this gene have been recently associated with hearing loss (HL).
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3D illustration of acute lymphoblastic leukemia in blood.
Cancer

ACHM-025, an AKR1C3-activated prodrug with efficacy in models of T-ALL

Feb. 17, 2023
Recent studies have demonstrated that T-ALL expresses significantly higher levels of the...
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Human sperm image
Genitourinary/Sexual Function

Soluble adenylyl cyclase inhibitor TDI-11861 blocks sperm mobility on-demand

Feb. 17, 2023
The majority of contraceptive methods currently in place target the female reproductive system by...
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Illustration of clot forming in blood vessel
Hematologic

Cereno focuses development of HDAC inhibitor CS-014 on thrombosis prevention

Feb. 17, 2023
Cereno Scientific AB has selected prevention of thrombosis as the target indication for its...
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Image of a cortical neuron expressing 5-HT2A receptors
Neurology/Psychiatric

Psychedelic drug effects: an inside job?

Feb. 17, 2023
By Anette Breindl
Psychedelic drugs may exert their effects at intracellular serotonin receptors that serotonin itself, which does not cross cell membranes, cannot reach. The findings were published in the Feb. 17, 2023, issue of Science by researchers from the University of California at Davis.
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Other news to note for Feb. 17, 2023

Feb. 17, 2023
Additional early-stage research and drug discovery news in brief, from: Celcuity, Neximmune.
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Immunofluorescence image of chromosomal instabilities
Cancer

Cancer’s chromosomal instability can be turned against itself

Feb. 16, 2023
By Mar de Miguel
In advanced or metastatic prostate cancer (PCa), patients may reach a stage where they do not respond to therapy. This stage is associated with chromosomal instability (CIN) and allow cells, up to a certain threshold, to adapt to therapy. However, a Mayo Clinic study has found a way to push that line so that cancer cells are so aberrant that they die.
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Cancer

Bristol Myers Squibb identifies new PD-1/PD-L1 interaction inhibitors

Feb. 16, 2023
Bristol Myers Squibb Co. has presented macrocyclic peptides acting as programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) interaction inhibitors reported to be useful for the treatment of cancer and infections.
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Cancer

Oncovalent Therapeutics presents new SAE1 inhibitors

Feb. 16, 2023
Oncovalent Therapeutics Inc. has identified SUMO-activating enzyme subunit 1 (SAE1) inhibitors reported to be useful for the treatment of cancer.
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