Novo Nordisk A/S has identified novel fatty acid modified urocortin 2 derivatives acting as CRF2 receptor agonists reported to be useful for the treatment of obesity and type 2 diabetes.
Otsuka Pharmaceutical Co. Ltd. has synthesized hydrogenated quinoxalines acting as serotonin and/or norepinephrine and/or dopamine reuptake inhibitors reported to be useful for the treatment of attention deficit hyperactivity disorder (ADHD).
Wigen Biomedicine Technology (Shanghai) Co. Ltd. has disclosed fused ring compounds acting as Wee1-like protein kinase (Wee1) inhibitors reported to be useful for the treatment of cancer.
The canonical Wnt signaling pathway participates in synapse function and stability, and previous research confirmed its impairment in Alzheimer's disease (AD).
Previous studies have revealed that the microbiome plays a role in the development and progression of some cancers and gut microbiome has been linked with immune homeostasis as well as antitumor immune responses. In the current study, scientists at the University of California, Davis aimed to evaluate the intratumoral microbiome in patients with nonmetastatic soft tissue sarcoma (STS) undergoing neoadjuvant radiotherapy (RT) and surgery.
Insulin secretion by pancreatic β cells is a fundamental component of glucose homeostasis. Aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a molecule involved in pancreatic β-cell dedifferentiation, leading to cell failure, and a marker of type 2 diabetes progression.
Atreca Inc. and Xencor Inc. have mutually selected the first program from their strategic collaboration combining an Atreca-discovered antibody with Xencor's Xmab bispecific Fc domain and a cytotoxic T-cell binding domain (CD3).
Harbour Biomed Ltd. has received IND clearance by the FDA to initiate clinical trials in the U.S. with HBM-1022, a monoclonal antibody generated from Harbour's integrated G protein-coupled receptor (GPCR) platform. The antibody can enhance antitumor immunity by depleting CCR8 positive regulatory T cells, activating effector T cells.
Ferlins are a family of single transmembrane proteins with multiple calcium ion (Ca2+) binding C2 domains involved in Ca2+-mediated membrane fusion. Among other processes, ferlins participate in the acrosome reaction occurring before spermatozoa fuse with eggs. Mutations in ferlins have been shown to cause male infertility in Caenorhabditis elegans and Drosophila melanogaster.
Satellos Bioscience Inc. has reported results from preclinical studies in a disease model of Duchenne muscular dystrophy (DMD). The company's proprietary Myoregenx assay platform identified a protein kinase (K9) as a potential drug target to modulate polarity in muscle stem cells.
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