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BioWorld - Friday, March 6, 2026
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Cancer

XM161-SN38 shows activity in models of glioma

Dec. 10, 2024
Researchers from Excellamol Inc. presented the design and preclinical characterization of XM161-SN38, a novel IL-13Rα2-targeting polypeptide-drug conjugate being evaluated for the treatment of gliomas.
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Prostate cancer cells
Cancer

ATC-324 targets prostate cancer AR mutants and splice variants

Dec. 10, 2024
Researchers from AUTOTAC Bio Inc. and affiliated organizations presented preclinical data for ATC-324, a novel autophagy-targeting chimera (AUTOTAC) designed to induce androgen receptor (AR) degradation.
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Drug design, drug delivery & technologies

Cimeio Therapeutics, Kyowa Kirin partner for cell therapies

Dec. 10, 2024
Cimeio Therapeutics Inc. has entered into a research collaboration with Kyowa Kirin Co. Ltd.
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Illustration of female reproductive system with cancer tissue on the cervix
Cancer

Oncolytic virus SONC-103 has activity in HPV16+ cervical cancer

Dec. 10, 2024
Chinese researchers presented a novel recombinant oncolytic HSV-1, named SONC-103.
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Neurology/psychiatric

Equity investment in Eikonizo supports HDAC6 inhibitor work

Dec. 10, 2024
Eikonizo Therapeutics Inc. has secured an equity investment from Novo Nordisk A/S.
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Gastrointestinal

NIDDK grant supports Orphagen’s RARα antagonist for inflammatory bowel disease

Dec. 10, 2024
Orphagen Pharmaceuticals Inc. has been granted an award of up to $1.7 million.
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Microscopic image of acute myeloid leukemia (AML) cells.
Immuno-oncology

MP-0621 combines cKit-targeting with conditional CD47 blockade

Dec. 10, 2024
With the aim of developing an effective and more tolerable conditioning for hematopoietic stem cell transplantation (HSCT), researchers from Molecular Partners AG applied the proprietary ankyrin repeat protein (DARPin) platform to generate a novel multi-specific Switch-DARPin candidate, MP-0621.
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Illustration of brain with electrical activity background
Neurology/psychiatric

BMB-101 5-HT2C biased agonist overcomes tolerance in chronic epilepsy treatment

Dec. 10, 2024
Researchers from Bright Minds Biosciences Inc. presented data on the mechanism of action of BMB-101, a novel scaffold 5-HT2C Gq-protein biased designed to treat drug-resistant neurological disorders.
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Immuno-oncology

DLK1-directed immunotherapy shows activity in neuroblastoma models

Dec. 10, 2024
Researchers from the Children's Hospital of Philadelphia presented data from a study that aimed to identify novel biologically relevant cell surface immunotherapeutic targets for neuroblastoma.
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Illustration of tumor
Cancer

Ideaya nominates IDE-892 as development candidate

Dec. 9, 2024
Ideaya Biosciences Inc. has nominated IDE-892, an MTA-cooperative PMRT5 inhibitor, as a development candidate.
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