Oxford University Innovations Ltd. has divulged Egl nine homolog 1 (EGLN1; HPH-2; PHD2) inhibitors reported to be useful for the treatment of anemia, ischemia, cardiovascular disorders, inflammatory disorders, irritable bowel syndrome, chronic kidney disease, Parkinson’s disease and Alzheimer’s disease, among others.
Researchers at Centre Hospitalier Universitaire de Grenoble Alpes, Centre National de la Recherche Scientifique, Commissariat à l’Energie Atomique, Institut National de la Santé et de la Recherche Médicale, Université Grenoble Alpes and Université Libre de Bruxelles have synthesized calix[4]arene compounds reported to be useful for treatment of cancer, metastatic cancer, and bacterial, viral, fungal and parasitic infections.
Zymedi Co. Ltd. has disclosed lysyl-tRNA synthetase (KARS)/laminin receptor (LR) interaction inhibitors reported to be useful for the treatment of cancer metastasis, autoimmune disease, inflammatory disorders, fibrosis and cardiovascular disorders.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, but has limited treatment options. Bile acids, gut microbiota, nuclear receptors, lipid metabolism and fatty acid metabolism are believed to play a role in MASLD treatment and prevention.
G protein-coupled receptor kinase 2 (GRK2) is a crucial kinase that has been shown to interact with multiple signaling molecules under different pathological conditions, including fibrosis.
Monopar Therapeutics Inc. has received Human Research Ethics Committee (HREC) clearance in Australia to initiate a phase I therapeutic trial of its novel radiopharmaceutical MNPR-101-Lu. MNPR-101-Lu combines the therapeutic radioisotope lutetium-177 (Lu-177) with Monopar’s proprietary first-in-class humanized monoclonal antibody MNPR-101, which is highly selective against the urokinase plasminogen activator receptor (uPAR).
Novel antimalarials are urgently needed to face the challenge of increasing parasite resistance. The isoprenoid precursor biosynthesis pathway is an attractive target for developing novel antimalarial drugs, being an essential and specific pathway in apicomplexan parasites.
Immpact Bio USA Inc. has obtained IND clearance from the FDA for IMPT-514, a CD19/CD20 bispecific chimeric antigen receptor (CAR) T-cell therapy for the treatment of adult patients with multiple sclerosis (MS). A phase I trial will focus on patients who have suboptimal disease control despite prior treatment with high efficacy disease-modifying therapies in all forms of MS.
Cycloicaritin (CICT) is a bioactive natural flavonoid extracted from Epimedium species with anti-inflammatory, antimicrobial or antiproliferative effects but with low bioavailability.
RSS
