Work at Beijing Earthwise Technology Co. Ltd. has led to the discovery of new protein arginine N-methyltransferase 5 (PRMT5) inhibitors potentially useful for the treatment of cancer.
An Allorion Therapeutics (Guangzhou) Co. Ltd. patent discloses aminoheteroaryl CDK4/cyclin D1 inhibitors reported to be useful for the treatment of cancer.
Celgene Corp. has identified substituted imidazopyrazine compounds characterized as interleukin-1 receptor-associated kinase 3 (IRAK-3; IRAK-M) ligands and thus reported to be useful for the treatment of cancer, autoimmune diseases and inflammatory disorders.
Quinoxaline derivatives acting as phosphatidylinositol 3-kinase α (PI3Kα) (H1047R mutant) and/or (E545K mutant) inhibitors have been described in a Black Diamond Therapeutics Inc. patent.
Shanghai Apeiron Biotechnology Co. Ltd. has patented new protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
Researchers from Chonnam National University presented novel a doxycycline (Doxy)-inducible gene switch system in attenuated Salmonella typhimurium, one of the bacterial strains that has been previously shown to selectively colonize and multiply in tumors, leading to oxygen deprivation, excessive nutrient leakage, and an antitumor immune response.
Enveric Biosciences Inc. has announced the discovery of multiple, promising novel compounds sourced using the company’s Psybrary platform and proprietary computational chemistry and artificial intelligence (AI) drug-discovery system (Psyai).
Survival in metastatic breast cancer has increased in recent years, but 5-year survival rates remain below 50% and the mechanisms of spreading remain to be elucidated. An emerging strategy to inhibit the progression of tumors consists of acting on tumor-associated macrophages to displace them from an M2-like phenotype to an M1-like phenotype.
Several metabolic alterations, including a preferential use of aerobic glycolysis, facilitate autonomous proliferation and survival of tumor cells. Although previous research suggested that active glycolysis in tumor cells is closely linked to genetic alterations, the underlying regulatory mechanisms remained unknown.
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