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Gene editing illustration
Cancer

Akribion successfully synthesizes constructs combining its G-dase E nuclease with Transcode’s TTX platform

March 12, 2024
Transcode Therapeutics Inc. has reported promising proof-of-concept laboratory studies in human cells, advancing its strategic partnership with Akribion Genomics AG.
Read More
Test tubes, dropper and capsules
Cancer

Eilean Therapeutics’ menin inhibitor cleared for first-in-human study in Australia

March 12, 2024
Eilean Therapeutics LLC has announced clearance by the Human Research Ethics Committee in Australia for a first-in-human phase I trial of balamenib (ZE63-0302), an oral small-molecule inhibitor of the menin-KMT2A interaction.
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Neurology/Psychiatric

STX-64 as potential new therapeutic approach for the treatment of AD and other cognitive-related diseases

March 12, 2024
The small-molecule steroid sulfatase (STS) inhibitor STX-64 (ONESTX-1, irosustat) previously showed a good safety and tolerability profile in several phase I and II clinical trials that evaluated the candidate for oncology indications.
Read More
Dry, thick and raised patches on the skin of knees and elbows
Biomarkers

Plasma galectins may aid in identifying metabolic complications in psoriasis

March 12, 2024
Work was conducted at the University of Bialystok to study plasma galectins (1, 2 and 12) plus serum and urinary levels of tumor necrosis factor (TNF), endothelin-1 (ET-1) and α1-acid-glycoprotein (α1AGP) in regards to the relationship between psoriasis and its related complications.
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Drug capsule spilling onto brain
Neurology/Psychiatric

Galimedix’s GAL-201 neutralizes Aβ-driven neurodegeneration

March 12, 2024
Recent findings have suggested GAL-201 from Galimedix Therapeutics Inc. is a robust oral candidate to treat Alzheimer’s disease (AD). GAL-201 binds to the misfolded form of amyloid-β (Aβ) monomers, thus preventing its aggregation and formation of neurotoxic oligomers and protofibrils.
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Cancer

Discovery of potent MALT1 inhibitors with synergetic antitumor effects in models of B-cell lymphoma

March 12, 2024
Researchers from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and affiliated organizations published preclinical data for a new class of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors being developed as candidates for the treatment of lymphoma.
Read More
Concept art for "unlocking the secrets of the mind"
Neurology/Psychiatric

AD/PD 2024: Insights into biological processes underlying neuronal dysfunction

March 11, 2024
By Coia Dulsat
The third day of the AD/PD 2024 conference in Lisbon started with a plenary lecture given by Professor Howard Fillit entitled, “Translating the biology of aging into new therapeutics for Alzheimer’s disease.” Fillit, a recognized neuroscientist and geriatrician, and co-founder of the Alzheimer’s Drug Discovery Foundation (ADDF), pointed to the geroscience hypothesis which postulates that targeting aging processes may result in preventive and therapeutic options for diseases of old age, including Alzheimer’s disease (AD).
Read More
Cancer

Kymera Therapeutics discovers new CDK2 degradation inducers for cancer

March 11, 2024
Kymera Therapeutics Inc. has described proteolysis targeting chimeras (PROTAC) compounds comprising an E3 ubiquitin ligase cereblon (CRBN)-binding moiety covalently linked to a cyclin-dependent kinase 2 (CDK2)-targeting moiety through a linker.
Read More
Cancer

Fochon Biosciences presents new Bcl-2 mutant inhibitors

March 11, 2024
Fochon Biosciences Ltd. has divulged apoptosis regulator Bcl-2 (D103E mutant and D103Y mutant) inhibitors reported to be useful for the treatment of autoimmune disease and cancer.
Read More
Cancer

Hotspot Therapeutics describes new MALT1 inhibitors for cancer

March 11, 2024
Hotspot Therapeutics Inc. has identified mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitors reported to be useful for the treatment of cancer.
Read More
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